Cancer targeting strategies in nanomedicine: Design and application of chitosan nanoparticles

Jun Pil Jee; Jin Hee Na; Sangmin Lee; Sun Hwa Kim; Kuiwon Choi; Yoon Yeo; Ick Chan Kwon

doi:10.1016/j.cossms.2013.01.002

Cancer targeting strategies in nanomedicine: Design and application of chitosan nanoparticles

Jun Pil Jee, Jin Hee Na, Sangmin Lee, Sun Hwa Kim, Kuiwon Choi, Yoon Yeo, Ick Chan Kwon

Research output: Contribution to journal › Review article › peer-review

53 Citations (Scopus)

Abstract

Nanomedicine has recently emerged as an efficient way of overcoming various limitations of conventional medicine, such as a lack of selectivity, poor pharmacokinetics and undesirable side effects. Especially, nanoparticles (NPs) technology has attracted more attentions in nanomedicine based approaches for cancer therapy due to unique physicochemical properties. Although NPs have been intensively studied for tumor targeting and showed some promising results, there is still limited understanding about pharmacokinetic (PK) and pharmacodynamic (PD) properties and tumor targeting efficiency of NPs. Thus, advances in understanding of these issues in NPs technology can create more opportunities to translate nanomedicine approaches into improved clinical outcomes. The goal of this review is to understand the key factors that are required for tumor targeted delivery of NPs. In addition, the review article more specifically describes important considerations in the formulation of chitosan nanoparticles such as particle size, shape, stiffness and deformability.

Original language	English
Pages (from-to)	333-342
Number of pages	10
Journal	Current Opinion in Solid State and Materials Science
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/j.cossms.2013.01.002
Publication status	Published - Dec 2012

Bibliographical note

Funding Information:
This work is supported by the GRL Program (2010-0019863) and Global Innovative Research Center program of the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology, by a grant of the Korea Healthcare technology R&D Project of Ministry for Health, Welfare & Family Affairs (A110879) and by the Intramural Research Program of KIST.

Keywords

Cancer targeting
Chitosan nanoparticle
Nanomedicine
Targeted drug delivery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cossms.2013.01.002

Cite this

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title = "Cancer targeting strategies in nanomedicine: Design and application of chitosan nanoparticles",

abstract = "Nanomedicine has recently emerged as an efficient way of overcoming various limitations of conventional medicine, such as a lack of selectivity, poor pharmacokinetics and undesirable side effects. Especially, nanoparticles (NPs) technology has attracted more attentions in nanomedicine based approaches for cancer therapy due to unique physicochemical properties. Although NPs have been intensively studied for tumor targeting and showed some promising results, there is still limited understanding about pharmacokinetic (PK) and pharmacodynamic (PD) properties and tumor targeting efficiency of NPs. Thus, advances in understanding of these issues in NPs technology can create more opportunities to translate nanomedicine approaches into improved clinical outcomes. The goal of this review is to understand the key factors that are required for tumor targeted delivery of NPs. In addition, the review article more specifically describes important considerations in the formulation of chitosan nanoparticles such as particle size, shape, stiffness and deformability.",

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author = "Jee, {Jun Pil} and Na, {Jin Hee} and Sangmin Lee and Kim, {Sun Hwa} and Kuiwon Choi and Yoon Yeo and Kwon, {Ick Chan}",

note = "Funding Information: This work is supported by the GRL Program (2010-0019863) and Global Innovative Research Center program of the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology, by a grant of the Korea Healthcare technology R&D Project of Ministry for Health, Welfare & Family Affairs (A110879) and by the Intramural Research Program of KIST.",

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doi = "10.1016/j.cossms.2013.01.002",

language = "English",

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AU - Lee, Sangmin

AU - Kim, Sun Hwa

AU - Choi, Kuiwon

AU - Yeo, Yoon

AU - Kwon, Ick Chan

N1 - Funding Information: This work is supported by the GRL Program (2010-0019863) and Global Innovative Research Center program of the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology, by a grant of the Korea Healthcare technology R&D Project of Ministry for Health, Welfare & Family Affairs (A110879) and by the Intramural Research Program of KIST.

PY - 2012/12

Y1 - 2012/12

N2 - Nanomedicine has recently emerged as an efficient way of overcoming various limitations of conventional medicine, such as a lack of selectivity, poor pharmacokinetics and undesirable side effects. Especially, nanoparticles (NPs) technology has attracted more attentions in nanomedicine based approaches for cancer therapy due to unique physicochemical properties. Although NPs have been intensively studied for tumor targeting and showed some promising results, there is still limited understanding about pharmacokinetic (PK) and pharmacodynamic (PD) properties and tumor targeting efficiency of NPs. Thus, advances in understanding of these issues in NPs technology can create more opportunities to translate nanomedicine approaches into improved clinical outcomes. The goal of this review is to understand the key factors that are required for tumor targeted delivery of NPs. In addition, the review article more specifically describes important considerations in the formulation of chitosan nanoparticles such as particle size, shape, stiffness and deformability.

AB - Nanomedicine has recently emerged as an efficient way of overcoming various limitations of conventional medicine, such as a lack of selectivity, poor pharmacokinetics and undesirable side effects. Especially, nanoparticles (NPs) technology has attracted more attentions in nanomedicine based approaches for cancer therapy due to unique physicochemical properties. Although NPs have been intensively studied for tumor targeting and showed some promising results, there is still limited understanding about pharmacokinetic (PK) and pharmacodynamic (PD) properties and tumor targeting efficiency of NPs. Thus, advances in understanding of these issues in NPs technology can create more opportunities to translate nanomedicine approaches into improved clinical outcomes. The goal of this review is to understand the key factors that are required for tumor targeted delivery of NPs. In addition, the review article more specifically describes important considerations in the formulation of chitosan nanoparticles such as particle size, shape, stiffness and deformability.

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KW - Targeted drug delivery

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Cancer targeting strategies in nanomedicine: Design and application of chitosan nanoparticles

Abstract

Bibliographical note

Keywords

UN SDGs

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