Cardiomyocyte contractile force changes in response to chemical environments

Jin You; Hyowon Moon; Boo Yong Lee; Ju Young Jin; Zi Eun Chang; Jun Kyo Francis Suh; Jinseok Kim; Jungyul Park; Yu Shik Hwang

doi:10.1109/NEMS.2014.6908796

Cardiomyocyte contractile force changes in response to chemical environments

Jin You
, Hyowon Moon
, Boo Yong Lee
, Ju Young Jin
, Zi Eun Chang
, Jun Kyo Francis Suh
, Jinseok Kim
, Jungyul Park
, Yu Shik Hwang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this study, we demonstrate that drug treatments change cardiomyocyte contractile force in vitro. Contractile force was determined by bending deflection of the cantilever end. We quantified the effect of Digoxin, Isoproterenol, and BayK8644, drugs that increase contractile force, on cardiomyocyte contractile forces when grown on the grooved cantilever. We also investigated the effect of Verapamil, which decreases contractile force. We applied Digoxin, Isoproterenol, and BayK8644 on day 8, and Verapamil on day 5. Digoxin, Isoproterenol, and BayK8644 increased cardiomyocyte contractile forces by 19.31%, 9.75%, and 23.81%, respectively. Verapamil decreased the contractile force by 48.06%. In summary, we monitored bending movement with cantilever sensors and concluded that cardiomyocyte contractile force changes in response to various drug treatments.

Original language	English
Title of host publication	9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	225-228
Number of pages	4
ISBN (Electronic)	9781479947270
DOIs	https://doi.org/10.1109/NEMS.2014.6908796
Publication status	Published - 23 Sept 2014
Event	9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014 - Waikiki Beach, United States Duration: 13 Apr 2014 → 16 Apr 2014

Publication series

Name	9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014

Conference

Conference	9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014
Country/Territory	United States
City	Waikiki Beach
Period	13/04/14 → 16/04/14

Bibliographical note

Publisher Copyright:
© 2014 IEEE.

Keywords

PDMS cantileve
cardiac contractile force
cardiomyocyte

Access to Document

10.1109/NEMS.2014.6908796

Cite this

You, J., Moon, H., Lee, B. Y., Jin, J. Y., Chang, Z. E., Suh, J. K. F., Kim, J., Park, J., & Hwang, Y. S. (2014). Cardiomyocyte contractile force changes in response to chemical environments. In 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014 (pp. 225-228). Article 6908796 (9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEMS.2014.6908796

You, Jin ; Moon, Hyowon ; Lee, Boo Yong et al. / Cardiomyocyte contractile force changes in response to chemical environments. 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 225-228 (9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014).

@inproceedings{7f4050acaf934185928fb30337ffc126,

title = "Cardiomyocyte contractile force changes in response to chemical environments",

abstract = "In this study, we demonstrate that drug treatments change cardiomyocyte contractile force in vitro. Contractile force was determined by bending deflection of the cantilever end. We quantified the effect of Digoxin, Isoproterenol, and BayK8644, drugs that increase contractile force, on cardiomyocyte contractile forces when grown on the grooved cantilever. We also investigated the effect of Verapamil, which decreases contractile force. We applied Digoxin, Isoproterenol, and BayK8644 on day 8, and Verapamil on day 5. Digoxin, Isoproterenol, and BayK8644 increased cardiomyocyte contractile forces by 19.31\%, 9.75\%, and 23.81\%, respectively. Verapamil decreased the contractile force by 48.06\%. In summary, we monitored bending movement with cantilever sensors and concluded that cardiomyocyte contractile force changes in response to various drug treatments.",

keywords = "PDMS cantileve, cardiac contractile force, cardiomyocyte",

author = "Jin You and Hyowon Moon and Lee, \{Boo Yong\} and Jin, \{Ju Young\} and Chang, \{Zi Eun\} and Suh, \{Jun Kyo Francis\} and Jinseok Kim and Jungyul Park and Hwang, \{Yu Shik\}",

note = "Publisher Copyright: {\textcopyright} 2014 IEEE.; 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014 ; Conference date: 13-04-2014 Through 16-04-2014",

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doi = "10.1109/NEMS.2014.6908796",

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series = "9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014",

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You, J, Moon, H, Lee, BY, Jin, JY, Chang, ZE, Suh, JKF, Kim, J, Park, J & Hwang, YS 2014, Cardiomyocyte contractile force changes in response to chemical environments. in 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014., 6908796, 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014, Institute of Electrical and Electronics Engineers Inc., pp. 225-228, 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014, Waikiki Beach, United States, 13/04/14. https://doi.org/10.1109/NEMS.2014.6908796

Cardiomyocyte contractile force changes in response to chemical environments. / You, Jin; Moon, Hyowon; Lee, Boo Yong et al.
9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 225-228 6908796 (9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Cardiomyocyte contractile force changes in response to chemical environments

AU - You, Jin

AU - Moon, Hyowon

AU - Lee, Boo Yong

AU - Jin, Ju Young

AU - Chang, Zi Eun

AU - Suh, Jun Kyo Francis

AU - Kim, Jinseok

AU - Park, Jungyul

AU - Hwang, Yu Shik

PY - 2014/9/23

Y1 - 2014/9/23

N2 - In this study, we demonstrate that drug treatments change cardiomyocyte contractile force in vitro. Contractile force was determined by bending deflection of the cantilever end. We quantified the effect of Digoxin, Isoproterenol, and BayK8644, drugs that increase contractile force, on cardiomyocyte contractile forces when grown on the grooved cantilever. We also investigated the effect of Verapamil, which decreases contractile force. We applied Digoxin, Isoproterenol, and BayK8644 on day 8, and Verapamil on day 5. Digoxin, Isoproterenol, and BayK8644 increased cardiomyocyte contractile forces by 19.31%, 9.75%, and 23.81%, respectively. Verapamil decreased the contractile force by 48.06%. In summary, we monitored bending movement with cantilever sensors and concluded that cardiomyocyte contractile force changes in response to various drug treatments.

AB - In this study, we demonstrate that drug treatments change cardiomyocyte contractile force in vitro. Contractile force was determined by bending deflection of the cantilever end. We quantified the effect of Digoxin, Isoproterenol, and BayK8644, drugs that increase contractile force, on cardiomyocyte contractile forces when grown on the grooved cantilever. We also investigated the effect of Verapamil, which decreases contractile force. We applied Digoxin, Isoproterenol, and BayK8644 on day 8, and Verapamil on day 5. Digoxin, Isoproterenol, and BayK8644 increased cardiomyocyte contractile forces by 19.31%, 9.75%, and 23.81%, respectively. Verapamil decreased the contractile force by 48.06%. In summary, we monitored bending movement with cantilever sensors and concluded that cardiomyocyte contractile force changes in response to various drug treatments.

KW - PDMS cantileve

KW - cardiac contractile force

KW - cardiomyocyte

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DO - 10.1109/NEMS.2014.6908796

M3 - Conference contribution

AN - SCOPUS:84908621116

T3 - 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014

SP - 225

EP - 228

BT - 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014

Y2 - 13 April 2014 through 16 April 2014

ER -

You J, Moon H, Lee BY, Jin JY, Chang ZE, Suh JKF et al. Cardiomyocyte contractile force changes in response to chemical environments. In 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014. Institute of Electrical and Electronics Engineers Inc. 2014. p. 225-228. 6908796. (9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014). doi: 10.1109/NEMS.2014.6908796

Cardiomyocyte contractile force changes in response to chemical environments

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Keywords

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