Causative agents of drug-induced pancreatitis: A nationwide assessment

Eun Kyoung Chung, Ji Hyun Lee, Dong Kee Jang, Sang Hyub Lee, Jin Ho Lee, Byung Joo Park, Kyenghee Kwon, Jun Kyu Lee

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Objectives The aim of this study was to analyze causes of drug-induced acute pancreatitis (DIAP) in Korea and factors associated with serious DIAP. Methods Case records of DIAP voluntarily reported to the Korea Adverse Event Reporting System from 2004 to 2013 were reviewed. When a patient took 2 or more drugs, each drug was identified as a potential cause. The seriousness of each case was determined based on the International Conference on Harmonization E2D Guideline. Logistic regression was performed to identify factors associated with the seriousness of DIAP. Results During the study period, 210 (0.05%) of 442,523 adverse event reports were (0.05%) DIAP. The most common causative medication of the DIAP cases with certain, probable/likely, and possible causality (n = 74) was l-asparaginase (n = 18), followed by azathioprine (n = 6), methylprednisolone (n = 6), and fenofibrate (n = 5). Serious events occurred in 43 cases (58%) with certain, probable/likely, and possible causality. They were significantly associated with the year of report (odds ratio, 0.572; P = 0.025) and the number of concurrently used medications (odds ratio, 2.659; P = 0.006). Conclusions l-Asparaginase is the most common cause of DIAP in Korea. Serious DIAP is more likely to occur in patients taking multiple medications.

Original languageEnglish
Pages (from-to)1328-1336
Number of pages9
JournalPancreas
Volume47
Issue number10
DOIs
Publication statusPublished - 1 Nov 2018

Bibliographical note

Publisher Copyright:
© 2018 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

  • adverse drug events
  • drug-induced acute pancreatitis
  • pharmacovigilance
  • polypharmacy

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