Cell-encapsulated 3D hydrogels with micro-pores and micro-channels

Jae Hong Park, Bong Geun Chung, Won Gu Lee, Jinseok Kim, Mark D. Brigham, Jaesool Shim, Seunghwan Lee, Changmo Hwang, Naside Gozde Durmus, Utkan Demirci, Ali Khademhosseini

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this project, an approach for engineering microporous 3D cell-laden hydrogel scaffolds was developed to improve the physical properties of microfluidic hydrogels such as high diffusivity and permeability. To enhance the diffusivity of macromolecules with the hydrogels, micropores were engineered by dissolution of sugar crystals. Microengineered scaffolds offer several advantages such as enhanced diffusion which could be beneficial for long term cell-culturing. Furthermore, it provides space for the settlement and proliferation of cells. Finally, microengineered pores provide biomimetic conditions similar to natural and porous tissues.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages518-521
Number of pages4
ISBN (Print)9780979806421
Publication statusPublished - 2009
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 1 Nov 20095 Nov 2009

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
Country/TerritoryKorea, Republic of
CityJeju
Period1/11/095/11/09

Keywords

  • 3D cell culture
  • Biomaterial
  • Biomimetic
  • Hydrogel
  • Microporous

Fingerprint

Dive into the research topics of 'Cell-encapsulated 3D hydrogels with micro-pores and micro-channels'. Together they form a unique fingerprint.

Cite this