Citromycin Isolated from the Antarctic Marine-Derived Fungi, Sporothrix sp., Inhibits Ovarian Cancer Cell Invasion via Suppression of ERK Signaling

He Yun Choi, Ji Hye Ahn, Haeun Kwon, Joung Han Yim, Dongho Lee, Jung Hye Choi

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, microorganisms and their metabolites in the Antarctic marine environment have attracted attention as useful sources for novel therapeutics, including anticancer drugs. Here, we investigated the effects of citromycin, isolated from the Antarctic marine-derived fungus, Sporothrix sp., on human ovarian cancer cells. Citromycin inhibited the migration and invasion of human ovarian cancer SKOV3 and A2780 cells, but had no cytotoxic activity against them. Additionally, it inhibited the expression of epithelial–mesenchymal transition (EMT) markers and the activation of matrix metalloproteinase (MMP)-2 and MMP9. Moreover, extracellular signal-regulated kinase (ERK)-1/2 signaling was inhibited after citromycin treatment, and the ectopic expression of ERK negated the anti-invasive activity of citromycin. Our findings suggest that citromycin inhibits the migration and invasion of human ovarian cancer cells by downregulating the expression levels of EMT markers and MMP-2/9 via inhibition of the ERK1/2 pathway.

Original languageEnglish
Article number275
JournalMarine Drugs
Volume20
Issue number5
DOIs
Publication statusPublished - May 2022

Keywords

  • citromycin
  • ERK1/2 pathway
  • invasion
  • MMP2 and MMP9
  • ovarian cancer
  • Sporothrix sp

Fingerprint

Dive into the research topics of 'Citromycin Isolated from the Antarctic Marine-Derived Fungi, Sporothrix sp., Inhibits Ovarian Cancer Cell Invasion via Suppression of ERK Signaling'. Together they form a unique fingerprint.

Cite this