Colloidal Fluorophore Aggregates for the Selective Detection of Albumins in Solution and on Electrophoresis Gels

Jihee Park, Youngmi Kim

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We report a fluorescent probe that is highly sensitive and selective for serum albumins. Signal transduction results from the disassembly of fluorescence-quenched aggregates upon binding to human serum albumin (HSA). The probe offers a rapid (≤2 s) fluorometric assay of HSA in phosphate-buffered saline, urine, or blood serum with a high signal-to-noise ratio. It is also useful as a wash-free prestaining reagent for detecting HSA on electrophoresis gels.

Original languageEnglish
Pages (from-to)350-354
Number of pages5
JournalChemBioChem
Volume20
Issue number3
DOIs
Publication statusPublished - 1 Feb 2019

Keywords

  • aggregation
  • fluorescence
  • imaging agents
  • proteins
  • self-assembly

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