Comparative study on the bone formation effect of platelet rich plasma(PRP) and platelet rich fibrin(PRF) in combination with the synthetic bone materials in rabbit cranial defects

Deok Won Lee, Kwang Ho Nam, Yu Jin Jee, Baek Soo Lee

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

To evaluate the clinical applicability of using PRF mixed with the synthetic bone materials compared to using PRP and no surgical additives. Four bicortical skull defects were prepared in 4 New Zealand white rabbits. In each, 1 defect was used as control and 3 defects were filled with HA/β-TCP, PRP mixed with HA/β-TCP, and PRF mixed with HA/β-TCP separately. After 8weeks, the rabbits were sacrificed and new bone formation was assessed by soft x-ray, conebeam CT and the histomorphometric analysis. Compared tocontrol group, the others showed remarkable bone formations. And PRP and PRF groups showed better results than no additive group. But there was no significant difference between PRP and PRF. The findings demonsatrates that the addition of PRP or PRF enhances bone formation. Though we cannot conclude PRF is superior to PRP from this study only, PRF can help the bone healing.

Original languageEnglish
Pages (from-to)265-272
Number of pages8
JournalTissue Engineering and Regenerative Medicine
Volume6
Issue number1-3
Publication statusPublished - Mar 2009

Keywords

  • β-TCP
  • Hydroxyapatite
  • Platelet rich fibrin
  • Platelet rich plasma
  • PRF
  • PRP

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