Comparison of cell-mediated immunity induced by three commercial single-dose Mycoplasma hyopneumoniae bacterins in pigs

Hwi Won Seo; Kiwon Han; Yeonsu Oh; Changhoon Park; Eun Jeong Choo; Sung Hoon Kim; Bog Hieu Lee; Chanhee Chae

doi:10.1292/jvms.12-0292

Comparison of cell-mediated immunity induced by three commercial single-dose Mycoplasma hyopneumoniae bacterins in pigs

Hwi Won Seo, Kiwon Han, Yeonsu Oh, Changhoon Park, Eun Jeong Choo, Sung Hoon Kim, Bog Hieu Lee, Chanhee Chae

Research output: Contribution to journal › Comment/debate

5 Citations (Scopus)

Abstract

This study was to compare the degree of cell-mediated immunity induced by three commercial Mycoplasma hyopneumoniae bacterins using interferon-γ (IFN-γ) measurements, lymphocyte stimulation assays and delayed-type hypersensitivity tests. Serum IFN-γ levels were significantly elevated in all four vaccinated pig groups at 21 days post-vaccination (P<0.05). Lymphocytes isolated 21 days postvaccination exhibited significantly more proliferation in response to M. hyopneumoniae than lymphocytes isolated 0 day pre-vaccination (P<0.05). Following intradermal injection of M. Hyopneumoniae antigen at 14, 21 or 28 days post-vaccination, all pigs in the four vaccinated groups displayed skin reactions characterized by circumscribed, often erythematous nodules. Taken together, these demonstrate that all three commercial single-dose M. hyopneumoniae bacterins used in this study induce varying degrees of cell-mediated immunity.

Original language	English
Pages (from-to)	245-247
Number of pages	3
Journal	Journal of Veterinary Medical Science
Volume	75
Issue number	2
DOIs	https://doi.org/10.1292/jvms.12-0292
Publication status	Published - 12 Oct 2012

Keywords

Cell-mediated immunity
Mycoplasma hyopneumoniae
Vaccination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1292/jvms.12-0292

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title = "Comparison of cell-mediated immunity induced by three commercial single-dose Mycoplasma hyopneumoniae bacterins in pigs",

abstract = "This study was to compare the degree of cell-mediated immunity induced by three commercial Mycoplasma hyopneumoniae bacterins using interferon-γ (IFN-γ) measurements, lymphocyte stimulation assays and delayed-type hypersensitivity tests. Serum IFN-γ levels were significantly elevated in all four vaccinated pig groups at 21 days post-vaccination (P<0.05). Lymphocytes isolated 21 days postvaccination exhibited significantly more proliferation in response to M. hyopneumoniae than lymphocytes isolated 0 day pre-vaccination (P<0.05). Following intradermal injection of M. Hyopneumoniae antigen at 14, 21 or 28 days post-vaccination, all pigs in the four vaccinated groups displayed skin reactions characterized by circumscribed, often erythematous nodules. Taken together, these demonstrate that all three commercial single-dose M. hyopneumoniae bacterins used in this study induce varying degrees of cell-mediated immunity.",

keywords = "Cell-mediated immunity, Mycoplasma hyopneumoniae, Vaccination",

author = "Seo, {Hwi Won} and Kiwon Han and Yeonsu Oh and Changhoon Park and Choo, {Eun Jeong} and Kim, {Sung Hoon} and Lee, {Bog Hieu} and Chanhee Chae",

year = "2012",

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doi = "10.1292/jvms.12-0292",

language = "English",

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AU - Seo, Hwi Won

AU - Han, Kiwon

AU - Oh, Yeonsu

AU - Park, Changhoon

AU - Choo, Eun Jeong

AU - Kim, Sung Hoon

AU - Lee, Bog Hieu

AU - Chae, Chanhee

PY - 2012/10/12

Y1 - 2012/10/12

N2 - This study was to compare the degree of cell-mediated immunity induced by three commercial Mycoplasma hyopneumoniae bacterins using interferon-γ (IFN-γ) measurements, lymphocyte stimulation assays and delayed-type hypersensitivity tests. Serum IFN-γ levels were significantly elevated in all four vaccinated pig groups at 21 days post-vaccination (P<0.05). Lymphocytes isolated 21 days postvaccination exhibited significantly more proliferation in response to M. hyopneumoniae than lymphocytes isolated 0 day pre-vaccination (P<0.05). Following intradermal injection of M. Hyopneumoniae antigen at 14, 21 or 28 days post-vaccination, all pigs in the four vaccinated groups displayed skin reactions characterized by circumscribed, often erythematous nodules. Taken together, these demonstrate that all three commercial single-dose M. hyopneumoniae bacterins used in this study induce varying degrees of cell-mediated immunity.

AB - This study was to compare the degree of cell-mediated immunity induced by three commercial Mycoplasma hyopneumoniae bacterins using interferon-γ (IFN-γ) measurements, lymphocyte stimulation assays and delayed-type hypersensitivity tests. Serum IFN-γ levels were significantly elevated in all four vaccinated pig groups at 21 days post-vaccination (P<0.05). Lymphocytes isolated 21 days postvaccination exhibited significantly more proliferation in response to M. hyopneumoniae than lymphocytes isolated 0 day pre-vaccination (P<0.05). Following intradermal injection of M. Hyopneumoniae antigen at 14, 21 or 28 days post-vaccination, all pigs in the four vaccinated groups displayed skin reactions characterized by circumscribed, often erythematous nodules. Taken together, these demonstrate that all three commercial single-dose M. hyopneumoniae bacterins used in this study induce varying degrees of cell-mediated immunity.

KW - Cell-mediated immunity

KW - Mycoplasma hyopneumoniae

KW - Vaccination

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U2 - 10.1292/jvms.12-0292

DO - 10.1292/jvms.12-0292

M3 - Comment/debate

C2 - 23059842

AN - SCOPUS:84874679470

SN - 0916-7250

VL - 75

SP - 245

EP - 247

JO - Journal of Veterinary Medical Science

JF - Journal of Veterinary Medical Science

IS - 2

ER -

Comparison of cell-mediated immunity induced by three commercial single-dose Mycoplasma hyopneumoniae bacterins in pigs

Abstract

Keywords

UN SDGs

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