Coordination-driven self-assembly and anticancer studies of thiophene-derived donor and arene ruthenium acceptors

Taegeun Kim; Hae Seong Song; Jatinder Singh; Donghyuk Kim; Hyunuk Kim; Se Chan Kang; Ki Whan Chi

doi:10.1016/j.ica.2018.05.035

Coordination-driven self-assembly and anticancer studies of thiophene-derived donor and arene ruthenium acceptors

Taegeun Kim
, Hae Seong Song
, Jatinder Singh
, Donghyuk Kim
, Hyunuk Kim
, Se Chan Kang
, Ki Whan Chi

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

New metallomacrocycles, 5–8, were synthesized by the coordination-driven self-assembly of thiophene-derived donor and arene ruthenium acceptors. Metallomacrocycles, 5–8, were fully characterized by ¹H, ¹³C NMR spectroscopy, ESI-MS and elemental analysis. The molecular structure of macrocycle 8 was determined by single-crystal X-ray diffraction analysis. In addition, the anticancer activities of metallomacrocycles 5–8 were evaluated. The cytotoxic potential of macrocycle 7 was assessed using several cancer cells with different origins using the Tali assay and by quantitative western blotting. The results obtained support the notion that macrocycle 7 induces apoptotic cell death by activating intrinsic and extrinsic apoptosis pathways.

Original language	English
Pages (from-to)	179-186
Number of pages	8
Journal	Inorganica Chimica Acta
Volume	482
DOIs	https://doi.org/10.1016/j.ica.2018.05.035
Publication status	Published - 1 Oct 2018

Bibliographical note

Publisher Copyright:
© 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer
Coordination-driven self-assembly
Metallomacrocycles
Thiophene

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10.1016/j.ica.2018.05.035

Cite this

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title = "Coordination-driven self-assembly and anticancer studies of thiophene-derived donor and arene ruthenium acceptors",

abstract = "New metallomacrocycles, 5{\textendash}8, were synthesized by the coordination-driven self-assembly of thiophene-derived donor and arene ruthenium acceptors. Metallomacrocycles, 5{\textendash}8, were fully characterized by 1H, 13C NMR spectroscopy, ESI-MS and elemental analysis. The molecular structure of macrocycle 8 was determined by single-crystal X-ray diffraction analysis. In addition, the anticancer activities of metallomacrocycles 5{\textendash}8 were evaluated. The cytotoxic potential of macrocycle 7 was assessed using several cancer cells with different origins using the Tali assay and by quantitative western blotting. The results obtained support the notion that macrocycle 7 induces apoptotic cell death by activating intrinsic and extrinsic apoptosis pathways.",

keywords = "Anticancer, Coordination-driven self-assembly, Metallomacrocycles, Thiophene",

author = "Taegeun Kim and Song, \{Hae Seong\} and Jatinder Singh and Donghyuk Kim and Hyunuk Kim and Kang, \{Se Chan\} and Chi, \{Ki Whan\}",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = oct,

day = "1",

doi = "10.1016/j.ica.2018.05.035",

language = "English",

volume = "482",

pages = "179--186",

journal = "Inorganica Chimica Acta",

issn = "0020-1693",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Coordination-driven self-assembly and anticancer studies of thiophene-derived donor and arene ruthenium acceptors

AU - Kim, Taegeun

AU - Song, Hae Seong

AU - Singh, Jatinder

AU - Kim, Donghyuk

AU - Kim, Hyunuk

AU - Kang, Se Chan

AU - Chi, Ki Whan

PY - 2018/10/1

Y1 - 2018/10/1

N2 - New metallomacrocycles, 5–8, were synthesized by the coordination-driven self-assembly of thiophene-derived donor and arene ruthenium acceptors. Metallomacrocycles, 5–8, were fully characterized by 1H, 13C NMR spectroscopy, ESI-MS and elemental analysis. The molecular structure of macrocycle 8 was determined by single-crystal X-ray diffraction analysis. In addition, the anticancer activities of metallomacrocycles 5–8 were evaluated. The cytotoxic potential of macrocycle 7 was assessed using several cancer cells with different origins using the Tali assay and by quantitative western blotting. The results obtained support the notion that macrocycle 7 induces apoptotic cell death by activating intrinsic and extrinsic apoptosis pathways.

AB - New metallomacrocycles, 5–8, were synthesized by the coordination-driven self-assembly of thiophene-derived donor and arene ruthenium acceptors. Metallomacrocycles, 5–8, were fully characterized by 1H, 13C NMR spectroscopy, ESI-MS and elemental analysis. The molecular structure of macrocycle 8 was determined by single-crystal X-ray diffraction analysis. In addition, the anticancer activities of metallomacrocycles 5–8 were evaluated. The cytotoxic potential of macrocycle 7 was assessed using several cancer cells with different origins using the Tali assay and by quantitative western blotting. The results obtained support the notion that macrocycle 7 induces apoptotic cell death by activating intrinsic and extrinsic apoptosis pathways.

KW - Anticancer

KW - Coordination-driven self-assembly

KW - Metallomacrocycles

KW - Thiophene

UR - https://www.scopus.com/pages/publications/85048543855

U2 - 10.1016/j.ica.2018.05.035

DO - 10.1016/j.ica.2018.05.035

M3 - Article

AN - SCOPUS:85048543855

SN - 0020-1693

VL - 482

SP - 179

EP - 186

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

ER -

Coordination-driven self-assembly and anticancer studies of thiophene-derived donor and arene ruthenium acceptors

Abstract

Bibliographical note

UN SDGs

Keywords

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