CXCR3 polymorphisms associated with risk of asthma

Sub Cheong Hyun; Choon Sik Park; Hyo Kim Lyoung; Lae Park Byung; Soo Taek Uh; Hooun Kim Yong; Gune Il Lym; Jong Young Lee; Jong Keuk Lee; Tae Kim Hung; Ha Jung Ryu; Ghee Han Bok; Woo Kim Jun; Chan Park; Kuchan Kimm; Doo Shin Hyoung; Bermseok Oh

doi:10.1016/j.bbrc.2005.07.019

CXCR3 polymorphisms associated with risk of asthma

Sub Cheong Hyun, Choon Sik Park, Hyo Kim Lyoung, Lae Park Byung, Soo Taek Uh, Hooun Kim Yong, Gune Il Lym, Jong Young Lee, Jong Keuk Lee, Tae Kim Hung, Ha Jung Ryu, Ghee Han Bok, Woo Kim Jun, Chan Park, Kuchan Kimm, Doo Shin Hyoung, Bermseok Oh

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21 Citations (Scopus)

Abstract

The chemokine (C-X-C motif) receptor 3 (CXCR3) gene, on chromosome Xq13, is known to have critical roles in inflammatory and immune responses. In an effort to discover polymorphisms have been implicated in asthma, we investigated the genetic polymorphisms in CXCR3 to evaluate it as a potential candidate gene for a host genetic study of asthma. Statistical analysis revealed that one SNP in intron 1, c.12+234G>A, showed significant association with the risk of asthma development (P = 0.007, OR = 0.81). By subgroup analyses stratified by gender and atopic status, the genetic effect of c.12+234G>A on asthma was more apparent among male atopic subjects (P = 0.0009, OR = 0.61). Our findings suggest that polymorphisms in CXCR3 might be one of the genetic factors for the risk of asthma development, especially in male atopic subjects. CXCR3 variation/haplotype information identified in this study will provide valuable information and insight into strategies for the control of asthma and its subgroup, atopy.

Original language	English
Pages (from-to)	1219-1225
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	334
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2005.07.019
Publication status	Published - 9 Sept 2005

Bibliographical note

Funding Information:
This work was supported by Grant No. M1-0302-00-0073 of the National Research Lab, part of the National Research and Development Program of the Ministry of Science and Technology of Korea.

Keywords

Association study
Asthma
Atopy
CXCR3
Chemokine receptor
Cytokine
Haplotype
Polymorphism
Sex diference
X chromosome

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10.1016/j.bbrc.2005.07.019

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Hyun, S. C., Park, C. S., Lyoung, H. K., Byung, L. P., Uh, S. T., Yong, H. K., Lym, G. I., Lee, J. Y., Lee, J. K., Hung, T. K., Ryu, H. J., Bok, G. H., Jun, W. K., Park, C., Kimm, K., Hyoung, D. S., & Oh, B. (2005). CXCR3 polymorphisms associated with risk of asthma. Biochemical and Biophysical Research Communications, 334(4), 1219-1225. https://doi.org/10.1016/j.bbrc.2005.07.019

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title = "CXCR3 polymorphisms associated with risk of asthma",

abstract = "The chemokine (C-X-C motif) receptor 3 (CXCR3) gene, on chromosome Xq13, is known to have critical roles in inflammatory and immune responses. In an effort to discover polymorphisms have been implicated in asthma, we investigated the genetic polymorphisms in CXCR3 to evaluate it as a potential candidate gene for a host genetic study of asthma. Statistical analysis revealed that one SNP in intron 1, c.12+234G>A, showed significant association with the risk of asthma development (P = 0.007, OR = 0.81). By subgroup analyses stratified by gender and atopic status, the genetic effect of c.12+234G>A on asthma was more apparent among male atopic subjects (P = 0.0009, OR = 0.61). Our findings suggest that polymorphisms in CXCR3 might be one of the genetic factors for the risk of asthma development, especially in male atopic subjects. CXCR3 variation/haplotype information identified in this study will provide valuable information and insight into strategies for the control of asthma and its subgroup, atopy.",

keywords = "Association study, Asthma, Atopy, CXCR3, Chemokine receptor, Cytokine, Haplotype, Polymorphism, Sex diference, X chromosome",

author = "Hyun, {Sub Cheong} and Park, {Choon Sik} and Lyoung, {Hyo Kim} and Byung, {Lae Park} and Uh, {Soo Taek} and Yong, {Hooun Kim} and Lym, {Gune Il} and Lee, {Jong Young} and Lee, {Jong Keuk} and Hung, {Tae Kim} and Ryu, {Ha Jung} and Bok, {Ghee Han} and Jun, {Woo Kim} and Chan Park and Kuchan Kimm and Hyoung, {Doo Shin} and Bermseok Oh",

note = "Funding Information: This work was supported by Grant No. M1-0302-00-0073 of the National Research Lab, part of the National Research and Development Program of the Ministry of Science and Technology of Korea. ",

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doi = "10.1016/j.bbrc.2005.07.019",

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T1 - CXCR3 polymorphisms associated with risk of asthma

AU - Hyun, Sub Cheong

AU - Park, Choon Sik

AU - Lyoung, Hyo Kim

AU - Byung, Lae Park

AU - Uh, Soo Taek

AU - Yong, Hooun Kim

AU - Lym, Gune Il

AU - Lee, Jong Young

AU - Lee, Jong Keuk

AU - Hung, Tae Kim

AU - Ryu, Ha Jung

AU - Bok, Ghee Han

AU - Jun, Woo Kim

AU - Park, Chan

AU - Kimm, Kuchan

AU - Hyoung, Doo Shin

AU - Oh, Bermseok

N1 - Funding Information: This work was supported by Grant No. M1-0302-00-0073 of the National Research Lab, part of the National Research and Development Program of the Ministry of Science and Technology of Korea.

PY - 2005/9/9

Y1 - 2005/9/9

N2 - The chemokine (C-X-C motif) receptor 3 (CXCR3) gene, on chromosome Xq13, is known to have critical roles in inflammatory and immune responses. In an effort to discover polymorphisms have been implicated in asthma, we investigated the genetic polymorphisms in CXCR3 to evaluate it as a potential candidate gene for a host genetic study of asthma. Statistical analysis revealed that one SNP in intron 1, c.12+234G>A, showed significant association with the risk of asthma development (P = 0.007, OR = 0.81). By subgroup analyses stratified by gender and atopic status, the genetic effect of c.12+234G>A on asthma was more apparent among male atopic subjects (P = 0.0009, OR = 0.61). Our findings suggest that polymorphisms in CXCR3 might be one of the genetic factors for the risk of asthma development, especially in male atopic subjects. CXCR3 variation/haplotype information identified in this study will provide valuable information and insight into strategies for the control of asthma and its subgroup, atopy.

AB - The chemokine (C-X-C motif) receptor 3 (CXCR3) gene, on chromosome Xq13, is known to have critical roles in inflammatory and immune responses. In an effort to discover polymorphisms have been implicated in asthma, we investigated the genetic polymorphisms in CXCR3 to evaluate it as a potential candidate gene for a host genetic study of asthma. Statistical analysis revealed that one SNP in intron 1, c.12+234G>A, showed significant association with the risk of asthma development (P = 0.007, OR = 0.81). By subgroup analyses stratified by gender and atopic status, the genetic effect of c.12+234G>A on asthma was more apparent among male atopic subjects (P = 0.0009, OR = 0.61). Our findings suggest that polymorphisms in CXCR3 might be one of the genetic factors for the risk of asthma development, especially in male atopic subjects. CXCR3 variation/haplotype information identified in this study will provide valuable information and insight into strategies for the control of asthma and its subgroup, atopy.

KW - Association study

KW - Asthma

KW - Atopy

KW - CXCR3

KW - Chemokine receptor

KW - Cytokine

KW - Haplotype

KW - Polymorphism

KW - Sex diference

KW - X chromosome

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U2 - 10.1016/j.bbrc.2005.07.019

DO - 10.1016/j.bbrc.2005.07.019

M3 - Article

C2 - 16043121

AN - SCOPUS:23044515102

SN - 0006-291X

VL - 334

SP - 1219

EP - 1225

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

CXCR3 polymorphisms associated with risk of asthma

Abstract

Bibliographical note

Keywords

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