Cytogenetic profiles of 2806 patients with acute myeloid leukemia—a retrospective multicenter nationwide study

Ja Min Byun; Young Jin Kim; Hwi Joong Yoon; Si Young Kim; Hee Je Kim; Jaeho Yoon; Yoo Hong Min; Jun Won Cheong; Jinny Park; Jae Hoon Lee; Dae Sik Hong; Seong Kyu Park; Hyeoung Joon Kim; Jae Sook Ahn; Ho Jin Shin; Joo Seop Chung; Won Sik Lee; Sang Min Lee; Yong Park; Byung Soo Kim; Je Hwan Lee; Kyoo Hyung Lee; Chul Won Jung; Jun Ho Jang; Woo Sung Min; Tae Sung Park

doi:10.1007/s00277-016-2691-1

Cytogenetic profiles of 2806 patients with acute myeloid leukemia—a retrospective multicenter nationwide study

Ja Min Byun, Young Jin Kim, Hwi Joong Yoon, Si Young Kim, Hee Je Kim, Jaeho Yoon, Yoo Hong Min, Jun Won Cheong, Jinny Park, Jae Hoon Lee, Dae Sik Hong, Seong Kyu Park, Hyeoung Joon Kim, Jae Sook Ahn, Ho Jin Shin, Joo Seop Chung, Won Sik Lee, Sang Min Lee, Yong Park, Byung Soo KimJe Hwan Lee, Kyoo Hyung Lee, Chul Won Jung, Jun Ho Jang, Woo Sung Min, Tae Sung Park

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16 Citations (Scopus)

Abstract

The cytogenetic and molecular data is recognized as the most valuable prognostic factor in acute myeloid leukemia (AML). Our aim was to systemically analyze the cytogenetics of Korean AML patients and to compare the cytogenetic profiles of various races to identify possible geographic heterogeneity. We retrospectively reviewed medical records of 2806 AML patients diagnosed at 11 tertiary teaching hospitals in Korea between January 2007 and December 2011. The most common recurrent chromosomal abnormality was t(8;21) (8.8 %, 238/2717), but t(15;17) showed an almost same number (8.6 %,235/2717). Among de novo AML, the most frequent aberrations were t(15;17), observed in 229 (10.7 %). The most common French-American-British (FAB) classification type was M2 (32.2 %), and recurrent cytogenetic abnormalities correlated with the FAB subtypes. Among 283 secondary AML cases, myelodysplastic syndrome was the most common predisposing factor. About 67.1 % of the secondary AML cases were associated with chromosomal aberrations, and chromosome 7 abnormalities (n = 45, 15.9 %) were most common. The incidence of FLT3 internal tandem duplication mutation was relatively low at 15 %. Our study reports certain similarities and differences in comparison to previous reports. Such discrepancies call for extensive epidemiological studies to clarify the role of genetic as well as geographic heterogeneity in the pathogenesis of AML.

Original language	English
Pages (from-to)	1223-1232
Number of pages	10
Journal	Annals of Hematology
Volume	95
Issue number	8
DOIs	https://doi.org/10.1007/s00277-016-2691-1
Publication status	Published - 1 Aug 2016

Bibliographical note

Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg.

Keywords

Acute myeloid leukemia
Chromosomal abnormalities
Cytogenetics
Population study

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10.1007/s00277-016-2691-1

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Byun, J. M., Kim, Y. J., Yoon, H. J., Kim, S. Y., Kim, H. J., Yoon, J., Min, Y. H., Cheong, J. W., Park, J., Lee, J. H., Hong, D. S., Park, S. K., Kim, H. J., Ahn, J. S., Shin, H. J., Chung, J. S., Lee, W. S., Lee, S. M., Park, Y., ... Park, T. S. (2016). Cytogenetic profiles of 2806 patients with acute myeloid leukemia—a retrospective multicenter nationwide study. Annals of Hematology, 95(8), 1223-1232. https://doi.org/10.1007/s00277-016-2691-1

@article{9d18eaad186f4a54ace700b3248fff5a,

title = "Cytogenetic profiles of 2806 patients with acute myeloid leukemia—a retrospective multicenter nationwide study",

abstract = "The cytogenetic and molecular data is recognized as the most valuable prognostic factor in acute myeloid leukemia (AML). Our aim was to systemically analyze the cytogenetics of Korean AML patients and to compare the cytogenetic profiles of various races to identify possible geographic heterogeneity. We retrospectively reviewed medical records of 2806 AML patients diagnosed at 11 tertiary teaching hospitals in Korea between January 2007 and December 2011. The most common recurrent chromosomal abnormality was t(8;21) (8.8 %, 238/2717), but t(15;17) showed an almost same number (8.6 %,235/2717). Among de novo AML, the most frequent aberrations were t(15;17), observed in 229 (10.7 %). The most common French-American-British (FAB) classification type was M2 (32.2 %), and recurrent cytogenetic abnormalities correlated with the FAB subtypes. Among 283 secondary AML cases, myelodysplastic syndrome was the most common predisposing factor. About 67.1 % of the secondary AML cases were associated with chromosomal aberrations, and chromosome 7 abnormalities (n = 45, 15.9 %) were most common. The incidence of FLT3 internal tandem duplication mutation was relatively low at 15 %. Our study reports certain similarities and differences in comparison to previous reports. Such discrepancies call for extensive epidemiological studies to clarify the role of genetic as well as geographic heterogeneity in the pathogenesis of AML.",

keywords = "Acute myeloid leukemia, Chromosomal abnormalities, Cytogenetics, Population study",

author = "Byun, {Ja Min} and Kim, {Young Jin} and Yoon, {Hwi Joong} and Kim, {Si Young} and Kim, {Hee Je} and Jaeho Yoon and Min, {Yoo Hong} and Cheong, {Jun Won} and Jinny Park and Lee, {Jae Hoon} and Hong, {Dae Sik} and Park, {Seong Kyu} and Kim, {Hyeoung Joon} and Ahn, {Jae Sook} and Shin, {Ho Jin} and Chung, {Joo Seop} and Lee, {Won Sik} and Lee, {Sang Min} and Yong Park and Kim, {Byung Soo} and Lee, {Je Hwan} and Lee, {Kyoo Hyung} and Jung, {Chul Won} and Jang, {Jun Ho} and Min, {Woo Sung} and Park, {Tae Sung}",

note = "Publisher Copyright: {\textcopyright} 2016, Springer-Verlag Berlin Heidelberg.",

year = "2016",

month = aug,

day = "1",

doi = "10.1007/s00277-016-2691-1",

language = "English",

volume = "95",

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Byun, JM, Kim, YJ, Yoon, HJ, Kim, SY, Kim, HJ, Yoon, J, Min, YH, Cheong, JW, Park, J, Lee, JH, Hong, DS, Park, SK, Kim, HJ, Ahn, JS, Shin, HJ, Chung, JS, Lee, WS, Lee, SM, Park, Y, Kim, BS, Lee, JH, Lee, KH, Jung, CW, Jang, JH, Min, WS & Park, TS 2016, 'Cytogenetic profiles of 2806 patients with acute myeloid leukemia—a retrospective multicenter nationwide study', Annals of Hematology, vol. 95, no. 8, pp. 1223-1232. https://doi.org/10.1007/s00277-016-2691-1

TY - JOUR

T1 - Cytogenetic profiles of 2806 patients with acute myeloid leukemia—a retrospective multicenter nationwide study

AU - Byun, Ja Min

AU - Kim, Young Jin

AU - Yoon, Hwi Joong

AU - Kim, Si Young

AU - Kim, Hee Je

AU - Yoon, Jaeho

AU - Min, Yoo Hong

AU - Cheong, Jun Won

AU - Park, Jinny

AU - Lee, Jae Hoon

AU - Hong, Dae Sik

AU - Park, Seong Kyu

AU - Kim, Hyeoung Joon

AU - Ahn, Jae Sook

AU - Shin, Ho Jin

AU - Chung, Joo Seop

AU - Lee, Won Sik

AU - Lee, Sang Min

AU - Park, Yong

AU - Kim, Byung Soo

AU - Lee, Je Hwan

AU - Lee, Kyoo Hyung

AU - Jung, Chul Won

AU - Jang, Jun Ho

AU - Min, Woo Sung

AU - Park, Tae Sung

PY - 2016/8/1

Y1 - 2016/8/1

N2 - The cytogenetic and molecular data is recognized as the most valuable prognostic factor in acute myeloid leukemia (AML). Our aim was to systemically analyze the cytogenetics of Korean AML patients and to compare the cytogenetic profiles of various races to identify possible geographic heterogeneity. We retrospectively reviewed medical records of 2806 AML patients diagnosed at 11 tertiary teaching hospitals in Korea between January 2007 and December 2011. The most common recurrent chromosomal abnormality was t(8;21) (8.8 %, 238/2717), but t(15;17) showed an almost same number (8.6 %,235/2717). Among de novo AML, the most frequent aberrations were t(15;17), observed in 229 (10.7 %). The most common French-American-British (FAB) classification type was M2 (32.2 %), and recurrent cytogenetic abnormalities correlated with the FAB subtypes. Among 283 secondary AML cases, myelodysplastic syndrome was the most common predisposing factor. About 67.1 % of the secondary AML cases were associated with chromosomal aberrations, and chromosome 7 abnormalities (n = 45, 15.9 %) were most common. The incidence of FLT3 internal tandem duplication mutation was relatively low at 15 %. Our study reports certain similarities and differences in comparison to previous reports. Such discrepancies call for extensive epidemiological studies to clarify the role of genetic as well as geographic heterogeneity in the pathogenesis of AML.

AB - The cytogenetic and molecular data is recognized as the most valuable prognostic factor in acute myeloid leukemia (AML). Our aim was to systemically analyze the cytogenetics of Korean AML patients and to compare the cytogenetic profiles of various races to identify possible geographic heterogeneity. We retrospectively reviewed medical records of 2806 AML patients diagnosed at 11 tertiary teaching hospitals in Korea between January 2007 and December 2011. The most common recurrent chromosomal abnormality was t(8;21) (8.8 %, 238/2717), but t(15;17) showed an almost same number (8.6 %,235/2717). Among de novo AML, the most frequent aberrations were t(15;17), observed in 229 (10.7 %). The most common French-American-British (FAB) classification type was M2 (32.2 %), and recurrent cytogenetic abnormalities correlated with the FAB subtypes. Among 283 secondary AML cases, myelodysplastic syndrome was the most common predisposing factor. About 67.1 % of the secondary AML cases were associated with chromosomal aberrations, and chromosome 7 abnormalities (n = 45, 15.9 %) were most common. The incidence of FLT3 internal tandem duplication mutation was relatively low at 15 %. Our study reports certain similarities and differences in comparison to previous reports. Such discrepancies call for extensive epidemiological studies to clarify the role of genetic as well as geographic heterogeneity in the pathogenesis of AML.

KW - Acute myeloid leukemia

KW - Chromosomal abnormalities

KW - Cytogenetics

KW - Population study

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DO - 10.1007/s00277-016-2691-1

M3 - Article

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AN - SCOPUS:84970024702

SN - 0939-5555

VL - 95

SP - 1223

EP - 1232

JO - Annals of Hematology

JF - Annals of Hematology

IS - 8

ER -

Cytogenetic profiles of 2806 patients with acute myeloid leukemia—a retrospective multicenter nationwide study

Abstract

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Keywords

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