Design and synthesis of novel antidiabetic agents

Yeol Lee Joon; Won Hui Park; Min Kyoung Cho; Jin Yun Hyun; Byung Ho Chung; Kim Pak Youngmi; Hoh Gyu Hahn; Hoon Cheon Seung

doi:10.1007/BF02977705

Design and synthesis of novel antidiabetic agents

Yeol Lee Joon
, Won Hui Park
, Min Kyoung Cho
, Jin Yun Hyun
, Byung Ho Chung
, Kim Pak Youngmi
, Hoh Gyu Hahn
, Hoon Cheon Seung

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The synthesis and structure-activity relationships of a novel series of substituted quercetins that activates peroxisome proliferator-activated receptor gamma (PPARγ) are reported. The PPARγ agonistic activity of the most potent compound in this series is comparable to that of the thiazolidinedione-based antidiabetic drugs currently in clinical use.

Original language	English
Pages (from-to)	142-150
Number of pages	9
Journal	Archives of Pharmacal Research
Volume	28
Issue number	2
DOIs	https://doi.org/10.1007/BF02977705
Publication status	Published - 28 Feb 2005

Bibliographical note

Funding Information:
This study was financially supported by Chonnam National University in the program, 2001.

Keywords

Antidiabetic agents
Malonate
Quercetin
Thiazolidinedione

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10.1007/BF02977705

Cite this

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title = "Design and synthesis of novel antidiabetic agents",

abstract = "The synthesis and structure-activity relationships of a novel series of substituted quercetins that activates peroxisome proliferator-activated receptor gamma (PPARγ) are reported. The PPARγ agonistic activity of the most potent compound in this series is comparable to that of the thiazolidinedione-based antidiabetic drugs currently in clinical use.",

keywords = "Antidiabetic agents, Malonate, Quercetin, Thiazolidinedione",

author = "Joon, \{Yeol Lee\} and Park, \{Won Hui\} and Cho, \{Min Kyoung\} and Hyun, \{Jin Yun\} and Chung, \{Byung Ho\} and Youngmi, \{Kim Pak\} and Hahn, \{Hoh Gyu\} and Seung, \{Hoon Cheon\}",

note = "Funding Information: This study was financially supported by Chonnam National University in the program, 2001.",

year = "2005",

month = feb,

day = "28",

doi = "10.1007/BF02977705",

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volume = "28",

pages = "142--150",

journal = "Archives of Pharmacal Research",

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TY - JOUR

T1 - Design and synthesis of novel antidiabetic agents

AU - Joon, Yeol Lee

AU - Park, Won Hui

AU - Cho, Min Kyoung

AU - Hyun, Jin Yun

AU - Chung, Byung Ho

AU - Youngmi, Kim Pak

AU - Hahn, Hoh Gyu

AU - Seung, Hoon Cheon

N1 - Funding Information: This study was financially supported by Chonnam National University in the program, 2001.

PY - 2005/2/28

Y1 - 2005/2/28

N2 - The synthesis and structure-activity relationships of a novel series of substituted quercetins that activates peroxisome proliferator-activated receptor gamma (PPARγ) are reported. The PPARγ agonistic activity of the most potent compound in this series is comparable to that of the thiazolidinedione-based antidiabetic drugs currently in clinical use.

AB - The synthesis and structure-activity relationships of a novel series of substituted quercetins that activates peroxisome proliferator-activated receptor gamma (PPARγ) are reported. The PPARγ agonistic activity of the most potent compound in this series is comparable to that of the thiazolidinedione-based antidiabetic drugs currently in clinical use.

KW - Antidiabetic agents

KW - Malonate

KW - Quercetin

KW - Thiazolidinedione

UR - https://www.scopus.com/pages/publications/21844433253

U2 - 10.1007/BF02977705

DO - 10.1007/BF02977705

M3 - Article

C2 - 15789741

AN - SCOPUS:21844433253

SN - 0253-6269

VL - 28

SP - 142

EP - 150

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 2

ER -

Design and synthesis of novel antidiabetic agents

Abstract

Bibliographical note

Keywords

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