Design of optimal solvent for extraction of bio-active ingredients from mulberry leaves

Jong Min Kim; Sang Mok Chang; In Ho Kim; Young Eun Kim; Ji Hwan Hwang; Kyo Seon Kim; Woo Sik Kim

doi:10.1016/j.bej.2007.05.006

Design of optimal solvent for extraction of bio-active ingredients from mulberry leaves

Jong Min Kim
, Sang Mok Chang
, In Ho Kim
, Young Eun Kim
, Ji Hwan Hwang
, Kyo Seon Kim
, Woo Sik Kim

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

A method of designing solvents for the optimal extraction of bio-active ingredients from natural resources was developed using an alcohol-water binary solvent. The target bio-active ingredient of polyphenols, anti-oxidation and anti-tyrosinase ingredients exhibited different dependency of extraction efficiency on the alcohol species (methanol, ethanol, n-propanol and i-propanol) and composition of binary solvent. Using the solubility parameter, the extraction efficiency of the bio-active ingredients was correlated with the solvent polarity. As a result, the optimal solvent polarities for the extraction of polyphenols, anti-oxidation and anti-tyrosinase ingredients were predicted as 38.5, 37.33, and 33.0 [MPa^1/2], respectively. These predictions also agreed well with the optimal solvent conditions of the water-alcohol mixtures depending on the alcohol species and composition. Plus, the correlation was confirmed with model solvents designed using other solvent species, including acetone and ethylene glycol.

Original language	English
Pages (from-to)	271-278
Number of pages	8
Journal	Biochemical Engineering Journal
Volume	37
Issue number	3
DOIs	https://doi.org/10.1016/j.bej.2007.05.006
Publication status	Published - 15 Dec 2007

Bibliographical note

Funding Information:
The authors are grateful for grants from the Korean Ministry of Health and Welfare (project no.: HMP-03-PJ1-PG1-CH14-0001).

Keywords

Alcohol-water binary solvent
Bio-active ingredients
Extraction
Solvent polarity

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10.1016/j.bej.2007.05.006

Cite this

@article{66b9ca6024ce4041bfe343d595fad097,

title = "Design of optimal solvent for extraction of bio-active ingredients from mulberry leaves",

abstract = "A method of designing solvents for the optimal extraction of bio-active ingredients from natural resources was developed using an alcohol-water binary solvent. The target bio-active ingredient of polyphenols, anti-oxidation and anti-tyrosinase ingredients exhibited different dependency of extraction efficiency on the alcohol species (methanol, ethanol, n-propanol and i-propanol) and composition of binary solvent. Using the solubility parameter, the extraction efficiency of the bio-active ingredients was correlated with the solvent polarity. As a result, the optimal solvent polarities for the extraction of polyphenols, anti-oxidation and anti-tyrosinase ingredients were predicted as 38.5, 37.33, and 33.0 [MPa1/2], respectively. These predictions also agreed well with the optimal solvent conditions of the water-alcohol mixtures depending on the alcohol species and composition. Plus, the correlation was confirmed with model solvents designed using other solvent species, including acetone and ethylene glycol.",

keywords = "Alcohol-water binary solvent, Bio-active ingredients, Extraction, Solvent polarity",

author = "Kim, \{Jong Min\} and Chang, \{Sang Mok\} and Kim, \{In Ho\} and Kim, \{Young Eun\} and Hwang, \{Ji Hwan\} and Kim, \{Kyo Seon\} and Kim, \{Woo Sik\}",

note = "Funding Information: The authors are grateful for grants from the Korean Ministry of Health and Welfare (project no.: HMP-03-PJ1-PG1-CH14-0001).",

year = "2007",

month = dec,

day = "15",

doi = "10.1016/j.bej.2007.05.006",

language = "English",

volume = "37",

pages = "271--278",

journal = "Biochemical Engineering Journal",

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T1 - Design of optimal solvent for extraction of bio-active ingredients from mulberry leaves

AU - Kim, Jong Min

AU - Chang, Sang Mok

AU - Kim, In Ho

AU - Kim, Young Eun

AU - Hwang, Ji Hwan

AU - Kim, Kyo Seon

AU - Kim, Woo Sik

N1 - Funding Information: The authors are grateful for grants from the Korean Ministry of Health and Welfare (project no.: HMP-03-PJ1-PG1-CH14-0001).

PY - 2007/12/15

Y1 - 2007/12/15

N2 - A method of designing solvents for the optimal extraction of bio-active ingredients from natural resources was developed using an alcohol-water binary solvent. The target bio-active ingredient of polyphenols, anti-oxidation and anti-tyrosinase ingredients exhibited different dependency of extraction efficiency on the alcohol species (methanol, ethanol, n-propanol and i-propanol) and composition of binary solvent. Using the solubility parameter, the extraction efficiency of the bio-active ingredients was correlated with the solvent polarity. As a result, the optimal solvent polarities for the extraction of polyphenols, anti-oxidation and anti-tyrosinase ingredients were predicted as 38.5, 37.33, and 33.0 [MPa1/2], respectively. These predictions also agreed well with the optimal solvent conditions of the water-alcohol mixtures depending on the alcohol species and composition. Plus, the correlation was confirmed with model solvents designed using other solvent species, including acetone and ethylene glycol.

AB - A method of designing solvents for the optimal extraction of bio-active ingredients from natural resources was developed using an alcohol-water binary solvent. The target bio-active ingredient of polyphenols, anti-oxidation and anti-tyrosinase ingredients exhibited different dependency of extraction efficiency on the alcohol species (methanol, ethanol, n-propanol and i-propanol) and composition of binary solvent. Using the solubility parameter, the extraction efficiency of the bio-active ingredients was correlated with the solvent polarity. As a result, the optimal solvent polarities for the extraction of polyphenols, anti-oxidation and anti-tyrosinase ingredients were predicted as 38.5, 37.33, and 33.0 [MPa1/2], respectively. These predictions also agreed well with the optimal solvent conditions of the water-alcohol mixtures depending on the alcohol species and composition. Plus, the correlation was confirmed with model solvents designed using other solvent species, including acetone and ethylene glycol.

KW - Alcohol-water binary solvent

KW - Bio-active ingredients

KW - Extraction

KW - Solvent polarity

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DO - 10.1016/j.bej.2007.05.006

M3 - Article

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SN - 1369-703X

VL - 37

SP - 271

EP - 278

JO - Biochemical Engineering Journal

JF - Biochemical Engineering Journal

IS - 3

ER -

Design of optimal solvent for extraction of bio-active ingredients from mulberry leaves

Abstract

Bibliographical note

Keywords

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