Development and characterisation of molecularly imprinted polymers based on methacrylic acid for selective recognition of drugs

Xizhi Shi; Aibo Wu; Guorun Qu; Rongxiu Li; Dabing Zhang

doi:10.1016/j.biomaterials.2007.04.036

Development and characterisation of molecularly imprinted polymers based on methacrylic acid for selective recognition of drugs

Xizhi Shi
, Aibo Wu
, Guorun Qu
, Rongxiu Li
, Dabing Zhang

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

Specific molecularly imprinted polymers (MIPs) for the drug reserpine (RES) using methacrylic acid (MAA) as the functional monomer were developed and characterised for the first time in this study. Evaluation of the various polymers by binding assays indicated that the optimum ratio of functional monomer to template was 4:1. Furthermore, the imprinting effect of the MIPs was assessed by the chromatographic method, which demonstrated that the MIPs had better chromatographic behavior and selectivity than those of the corresponding NIPs. A combination of BET, NMR, UV spectroscopy, and MISPE analyses for investigation of the imprinting and recognition properties revealed that strong specific interactions between the functional monomer and RES in the prepolymerization solutions and the aqueous solutions were probably responsible for RES recognition. The preparation of RES MIPs and elucidation of imprinting and recognition mechanisms may serve as useful references for other drug MIPs.

Original language	English
Pages (from-to)	3741-3749
Number of pages	9
Journal	Biomaterials
Volume	28
Issue number	25
DOIs	https://doi.org/10.1016/j.biomaterials.2007.04.036
Publication status	Published - Sept 2007

Bibliographical note

Funding Information:
This work was supported by a grant from the National “863” High-Tech Project (2006AA10Z438), the National Key Project of Scientific and Technical Supporting Programs Funded by Ministry of Science & Technology of China (NO.2006BAK02A09) and Shanghai Nano-tech Special Fund (0652nm017). The authors are grateful to the Instrumental Analysis Center of Shanghai Jiao Tong University, China for SEM photography. We are grateful to Dr. Tom Hsiang (University of Guelph, Canada) for technical language editing.

Keywords

Drugs
Molecularly imprinted polymers
Reserpine
Solid-phase extraction

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10.1016/j.biomaterials.2007.04.036

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title = "Development and characterisation of molecularly imprinted polymers based on methacrylic acid for selective recognition of drugs",

abstract = "Specific molecularly imprinted polymers (MIPs) for the drug reserpine (RES) using methacrylic acid (MAA) as the functional monomer were developed and characterised for the first time in this study. Evaluation of the various polymers by binding assays indicated that the optimum ratio of functional monomer to template was 4:1. Furthermore, the imprinting effect of the MIPs was assessed by the chromatographic method, which demonstrated that the MIPs had better chromatographic behavior and selectivity than those of the corresponding NIPs. A combination of BET, NMR, UV spectroscopy, and MISPE analyses for investigation of the imprinting and recognition properties revealed that strong specific interactions between the functional monomer and RES in the prepolymerization solutions and the aqueous solutions were probably responsible for RES recognition. The preparation of RES MIPs and elucidation of imprinting and recognition mechanisms may serve as useful references for other drug MIPs.",

keywords = "Drugs, Molecularly imprinted polymers, Reserpine, Solid-phase extraction",

author = "Xizhi Shi and Aibo Wu and Guorun Qu and Rongxiu Li and Dabing Zhang",

note = "Funding Information: This work was supported by a grant from the National {\textquotedblleft}863{\textquotedblright} High-Tech Project (2006AA10Z438), the National Key Project of Scientific and Technical Supporting Programs Funded by Ministry of Science \& Technology of China (NO.2006BAK02A09) and Shanghai Nano-tech Special Fund (0652nm017). The authors are grateful to the Instrumental Analysis Center of Shanghai Jiao Tong University, China for SEM photography. We are grateful to Dr. Tom Hsiang (University of Guelph, Canada) for technical language editing.",

year = "2007",

month = sep,

doi = "10.1016/j.biomaterials.2007.04.036",

language = "English",

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AU - Shi, Xizhi

AU - Wu, Aibo

AU - Qu, Guorun

AU - Li, Rongxiu

AU - Zhang, Dabing

N1 - Funding Information: This work was supported by a grant from the National “863” High-Tech Project (2006AA10Z438), the National Key Project of Scientific and Technical Supporting Programs Funded by Ministry of Science & Technology of China (NO.2006BAK02A09) and Shanghai Nano-tech Special Fund (0652nm017). The authors are grateful to the Instrumental Analysis Center of Shanghai Jiao Tong University, China for SEM photography. We are grateful to Dr. Tom Hsiang (University of Guelph, Canada) for technical language editing.

PY - 2007/9

Y1 - 2007/9

N2 - Specific molecularly imprinted polymers (MIPs) for the drug reserpine (RES) using methacrylic acid (MAA) as the functional monomer were developed and characterised for the first time in this study. Evaluation of the various polymers by binding assays indicated that the optimum ratio of functional monomer to template was 4:1. Furthermore, the imprinting effect of the MIPs was assessed by the chromatographic method, which demonstrated that the MIPs had better chromatographic behavior and selectivity than those of the corresponding NIPs. A combination of BET, NMR, UV spectroscopy, and MISPE analyses for investigation of the imprinting and recognition properties revealed that strong specific interactions between the functional monomer and RES in the prepolymerization solutions and the aqueous solutions were probably responsible for RES recognition. The preparation of RES MIPs and elucidation of imprinting and recognition mechanisms may serve as useful references for other drug MIPs.

AB - Specific molecularly imprinted polymers (MIPs) for the drug reserpine (RES) using methacrylic acid (MAA) as the functional monomer were developed and characterised for the first time in this study. Evaluation of the various polymers by binding assays indicated that the optimum ratio of functional monomer to template was 4:1. Furthermore, the imprinting effect of the MIPs was assessed by the chromatographic method, which demonstrated that the MIPs had better chromatographic behavior and selectivity than those of the corresponding NIPs. A combination of BET, NMR, UV spectroscopy, and MISPE analyses for investigation of the imprinting and recognition properties revealed that strong specific interactions between the functional monomer and RES in the prepolymerization solutions and the aqueous solutions were probably responsible for RES recognition. The preparation of RES MIPs and elucidation of imprinting and recognition mechanisms may serve as useful references for other drug MIPs.

KW - Drugs

KW - Molecularly imprinted polymers

KW - Reserpine

KW - Solid-phase extraction

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DO - 10.1016/j.biomaterials.2007.04.036

M3 - Article

C2 - 17512050

AN - SCOPUS:34249883340

SN - 0142-9612

VL - 28

SP - 3741

EP - 3749

JO - Biomaterials

JF - Biomaterials

IS - 25

ER -

Development and characterisation of molecularly imprinted polymers based on methacrylic acid for selective recognition of drugs

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