Development of an oral immunoadjuvant from cheonggukjang that is efficacious for both mucosal and systemic immunity

Inkyu Hwang; Daewoon Choi; Hyejeong See; Seong Il Lim; Wonyong Kim; In Sik Chung; Dong Hwa Shon

doi:10.1007/s10068-014-0033-4

Development of an oral immunoadjuvant from cheonggukjang that is efficacious for both mucosal and systemic immunity

Inkyu Hwang
, Daewoon Choi
, Hyejeong See
, Seong Il Lim
, Wonyong Kim
, In Sik Chung
, Dong Hwa Shon

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Immunological properties of a 50% ethanol/aqueous extract of cheonggukjang (CGJ), a fermented soybean product, were investigated as a potent, orallyavailable, and cost-effective immunoadjuvant. Different from cholera toxin, a widely used experimental oral adjuvant with effects limited to mucosal immunity in the gut, oraladministration of the CGJ extract had positive effects on both mucosal and systemic immunity. Administration of keyhole limpet hemocyanin (KLH) with the CGJ extract resulted in hyper-production of KLH-specific IgA in the gut and KLH-specific IgG in the serum. Oral-administration of the CGJ extract resulted in promotion of both Th1 and Th2 immune responses, thus eliminating concerns over an imbalanced Th1 and Th2 immune bias that is often observed upon administration of other commonly used immunoadjuvants. Ethanol/aqueous extraction of CGJ resulted in enrichment of polyphenolic compounds, including flavonoids, providing a potential extra health benefit.

Original language	English
Pages (from-to)	239-245
Number of pages	7
Journal	Food Science and Biotechnology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1007/s10068-014-0033-4
Publication status	Published - Feb 2014

Bibliographical note

Funding Information:
Acknowledgments This work was supported by research grants from the Korea Food Research Institute and the Next Generation BioGreen 21 Program (No. PJ006746), Rural Development Administration, Republic of Korea.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

adjuvant
cheonggukjang
fermented food
mucosal immunity
oral vaccine

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10.1007/s10068-014-0033-4

Cite this

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title = "Development of an oral immunoadjuvant from cheonggukjang that is efficacious for both mucosal and systemic immunity",

abstract = "Immunological properties of a 50\% ethanol/aqueous extract of cheonggukjang (CGJ), a fermented soybean product, were investigated as a potent, orallyavailable, and cost-effective immunoadjuvant. Different from cholera toxin, a widely used experimental oral adjuvant with effects limited to mucosal immunity in the gut, oraladministration of the CGJ extract had positive effects on both mucosal and systemic immunity. Administration of keyhole limpet hemocyanin (KLH) with the CGJ extract resulted in hyper-production of KLH-specific IgA in the gut and KLH-specific IgG in the serum. Oral-administration of the CGJ extract resulted in promotion of both Th1 and Th2 immune responses, thus eliminating concerns over an imbalanced Th1 and Th2 immune bias that is often observed upon administration of other commonly used immunoadjuvants. Ethanol/aqueous extraction of CGJ resulted in enrichment of polyphenolic compounds, including flavonoids, providing a potential extra health benefit.",

keywords = "adjuvant, cheonggukjang, fermented food, mucosal immunity, oral vaccine",

author = "Inkyu Hwang and Daewoon Choi and Hyejeong See and Lim, \{Seong Il\} and Wonyong Kim and Chung, \{In Sik\} and Shon, \{Dong Hwa\}",

note = "Funding Information: Acknowledgments This work was supported by research grants from the Korea Food Research Institute and the Next Generation BioGreen 21 Program (No. PJ006746), Rural Development Administration, Republic of Korea.",

year = "2014",

month = feb,

doi = "10.1007/s10068-014-0033-4",

language = "English",

volume = "23",

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T1 - Development of an oral immunoadjuvant from cheonggukjang that is efficacious for both mucosal and systemic immunity

AU - Hwang, Inkyu

AU - Choi, Daewoon

AU - See, Hyejeong

AU - Lim, Seong Il

AU - Kim, Wonyong

AU - Chung, In Sik

AU - Shon, Dong Hwa

N1 - Funding Information: Acknowledgments This work was supported by research grants from the Korea Food Research Institute and the Next Generation BioGreen 21 Program (No. PJ006746), Rural Development Administration, Republic of Korea.

PY - 2014/2

Y1 - 2014/2

N2 - Immunological properties of a 50% ethanol/aqueous extract of cheonggukjang (CGJ), a fermented soybean product, were investigated as a potent, orallyavailable, and cost-effective immunoadjuvant. Different from cholera toxin, a widely used experimental oral adjuvant with effects limited to mucosal immunity in the gut, oraladministration of the CGJ extract had positive effects on both mucosal and systemic immunity. Administration of keyhole limpet hemocyanin (KLH) with the CGJ extract resulted in hyper-production of KLH-specific IgA in the gut and KLH-specific IgG in the serum. Oral-administration of the CGJ extract resulted in promotion of both Th1 and Th2 immune responses, thus eliminating concerns over an imbalanced Th1 and Th2 immune bias that is often observed upon administration of other commonly used immunoadjuvants. Ethanol/aqueous extraction of CGJ resulted in enrichment of polyphenolic compounds, including flavonoids, providing a potential extra health benefit.

AB - Immunological properties of a 50% ethanol/aqueous extract of cheonggukjang (CGJ), a fermented soybean product, were investigated as a potent, orallyavailable, and cost-effective immunoadjuvant. Different from cholera toxin, a widely used experimental oral adjuvant with effects limited to mucosal immunity in the gut, oraladministration of the CGJ extract had positive effects on both mucosal and systemic immunity. Administration of keyhole limpet hemocyanin (KLH) with the CGJ extract resulted in hyper-production of KLH-specific IgA in the gut and KLH-specific IgG in the serum. Oral-administration of the CGJ extract resulted in promotion of both Th1 and Th2 immune responses, thus eliminating concerns over an imbalanced Th1 and Th2 immune bias that is often observed upon administration of other commonly used immunoadjuvants. Ethanol/aqueous extraction of CGJ resulted in enrichment of polyphenolic compounds, including flavonoids, providing a potential extra health benefit.

KW - adjuvant

KW - cheonggukjang

KW - fermented food

KW - mucosal immunity

KW - oral vaccine

UR - https://www.scopus.com/pages/publications/84894461899

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DO - 10.1007/s10068-014-0033-4

M3 - Article

AN - SCOPUS:84894461899

SN - 1226-7708

VL - 23

SP - 239

EP - 245

JO - Food Science and Biotechnology

JF - Food Science and Biotechnology

IS - 1

ER -

Development of an oral immunoadjuvant from cheonggukjang that is efficacious for both mucosal and systemic immunity

Abstract

Bibliographical note

UN SDGs

Keywords

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