Disodium cromoglycate inhibits production of immunoglobulin E

Sang Bong Seo; Seok Jae Park; Seung Taeck Park; Chung Cu Cho; Byung Hyun Park; Seung Jae Lee; Hyung Min Kim; Toshio Kajiuchi; Tae Yong Shin

doi:10.1081/IPH-100103862

Disodium cromoglycate inhibits production of immunoglobulin E

Sang Bong Seo
, Seok Jae Park
, Seung Taeck Park
, Chung Cu Cho
, Byung Hyun Park
, Seung Jae Lee
, Hyung Min Kim
, Toshio Kajiuchi
, Tae Yong Shin

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Disodium cromoglycate (DSCG) has been shown to inhibit the release of mediators from mast cells. In the present study, the effect of DSCG on active anaphylactic reaction was studied in mice. DSCG dose-dependently inhibited the active systemic anaphylactic reaction and serum immunoglobulin (Ig)E production induced by immunization with ovalbumin, Bordetella pertussis toxin and aluminum hydroxide gel. DSCG strongly inhibited IL-4-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, DSCG also showed an inhibitory effect on the IgE production. These results suggest that DSCG has an anti-anaphylactic activity by inhibition of IgE production from B cells.

Original language	English
Pages (from-to)	229-237
Number of pages	9
Journal	Immunopharmacology and Immunotoxicology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1081/IPH-100103862
Publication status	Published - 2001

Bibliographical note

Funding Information:
This work was supported by Wonkwang University in 2000 and partially by JAKWANG Co., Ltd.

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10.1081/IPH-100103862

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title = "Disodium cromoglycate inhibits production of immunoglobulin E",

abstract = "Disodium cromoglycate (DSCG) has been shown to inhibit the release of mediators from mast cells. In the present study, the effect of DSCG on active anaphylactic reaction was studied in mice. DSCG dose-dependently inhibited the active systemic anaphylactic reaction and serum immunoglobulin (Ig)E production induced by immunization with ovalbumin, Bordetella pertussis toxin and aluminum hydroxide gel. DSCG strongly inhibited IL-4-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, DSCG also showed an inhibitory effect on the IgE production. These results suggest that DSCG has an anti-anaphylactic activity by inhibition of IgE production from B cells.",

author = "Seo, \{Sang Bong\} and Park, \{Seok Jae\} and Park, \{Seung Taeck\} and Cho, \{Chung Cu\} and Park, \{Byung Hyun\} and Lee, \{Seung Jae\} and Kim, \{Hyung Min\} and Toshio Kajiuchi and Shin, \{Tae Yong\}",

note = "Funding Information: This work was supported by Wonkwang University in 2000 and partially by JAKWANG Co., Ltd.",

year = "2001",

doi = "10.1081/IPH-100103862",

language = "English",

volume = "23",

pages = "229--237",

journal = "Immunopharmacology and Immunotoxicology",

issn = "0892-3973",

publisher = "Taylor and Francis Ltd.",

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}

TY - JOUR

T1 - Disodium cromoglycate inhibits production of immunoglobulin E

AU - Seo, Sang Bong

AU - Park, Seok Jae

AU - Park, Seung Taeck

AU - Cho, Chung Cu

AU - Park, Byung Hyun

AU - Lee, Seung Jae

AU - Kim, Hyung Min

AU - Kajiuchi, Toshio

AU - Shin, Tae Yong

N1 - Funding Information: This work was supported by Wonkwang University in 2000 and partially by JAKWANG Co., Ltd.

PY - 2001

Y1 - 2001

N2 - Disodium cromoglycate (DSCG) has been shown to inhibit the release of mediators from mast cells. In the present study, the effect of DSCG on active anaphylactic reaction was studied in mice. DSCG dose-dependently inhibited the active systemic anaphylactic reaction and serum immunoglobulin (Ig)E production induced by immunization with ovalbumin, Bordetella pertussis toxin and aluminum hydroxide gel. DSCG strongly inhibited IL-4-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, DSCG also showed an inhibitory effect on the IgE production. These results suggest that DSCG has an anti-anaphylactic activity by inhibition of IgE production from B cells.

AB - Disodium cromoglycate (DSCG) has been shown to inhibit the release of mediators from mast cells. In the present study, the effect of DSCG on active anaphylactic reaction was studied in mice. DSCG dose-dependently inhibited the active systemic anaphylactic reaction and serum immunoglobulin (Ig)E production induced by immunization with ovalbumin, Bordetella pertussis toxin and aluminum hydroxide gel. DSCG strongly inhibited IL-4-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, DSCG also showed an inhibitory effect on the IgE production. These results suggest that DSCG has an anti-anaphylactic activity by inhibition of IgE production from B cells.

UR - https://www.scopus.com/pages/publications/0034995699

U2 - 10.1081/IPH-100103862

DO - 10.1081/IPH-100103862

M3 - Article

C2 - 11417850

AN - SCOPUS:0034995699

SN - 0892-3973

VL - 23

SP - 229

EP - 237

JO - Immunopharmacology and Immunotoxicology

JF - Immunopharmacology and Immunotoxicology

IS - 2

ER -

Disodium cromoglycate inhibits production of immunoglobulin E

Abstract

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