Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

Ahn Na Koo; Hong Jae Lee; Sung Eun Kim; Jeong Ho Chang; Chiyoung Park; Chulhee Kim; Jae Hyung Park; Sang Cheon Lee

doi:10.1039/b815918a

Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

Ahn Na Koo, Hong Jae Lee, Sung Eun Kim, Jeong Ho Chang, Chiyoung Park, Chulhee Kim, Jae Hyung Park, Sang Cheon Lee

Research output: Contribution to journal › Article › peer-review

389 Citations (Scopus)

Abstract

We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.

Original language	English
Pages (from-to)	6570-6572
Number of pages	3
Journal	Chemical Communications
Issue number	48
DOIs	https://doi.org/10.1039/b815918a
Publication status	Published - 2008

Access to Document

10.1039/b815918a

Cite this

@article{a7df3025bbe84fc6aac37444e85a14f1,

title = "Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery",

abstract = "We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.",

author = "Koo, {Ahn Na} and Lee, {Hong Jae} and Kim, {Sung Eun} and Chang, {Jeong Ho} and Chiyoung Park and Chulhee Kim and Park, {Jae Hyung} and Lee, {Sang Cheon}",

year = "2008",

doi = "10.1039/b815918a",

language = "English",

pages = "6570--6572",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "48",

}

TY - JOUR

T1 - Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

AU - Koo, Ahn Na

AU - Lee, Hong Jae

AU - Kim, Sung Eun

AU - Chang, Jeong Ho

AU - Park, Chiyoung

AU - Kim, Chulhee

AU - Park, Jae Hyung

AU - Lee, Sang Cheon

PY - 2008

Y1 - 2008

N2 - We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.

AB - We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.

UR - http://www.scopus.com/inward/record.url?scp=57349111147&partnerID=8YFLogxK

U2 - 10.1039/b815918a

DO - 10.1039/b815918a

M3 - Article

C2 - 19057782

AN - SCOPUS:57349111147

SN - 1359-7345

SP - 6570

EP - 6572

JO - Chemical Communications

JF - Chemical Communications

IS - 48

ER -

Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

Abstract

Access to Document

Other files and links

Fingerprint

Cite this