Doxycycline-loaded nitric oxide-releasing nanomatrix gel in replanted rat molar on pulp regeneration

Kwan Hee Yun, Mi Ja Ko, Yong Kown Chae, Koeun Lee, Ok Hyung Nam, Hyo Seol Lee, Kyounga Cheon, Sung Chul Choi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The aim of the present study was to evaluate the effect of doxycycline-loaded NO-releasing nanomatrix gel on pulp regeneration in replantation of avulsed rat teeth. A total of 28 maxillary first molars extracted from rats were replanted. The rats were divided into two groups based on the use of root surface treatment: doxycycline-loaded NO-releasing nanomatrix group and no treat-ment. Eight weeks after replantation, the rats were sacrificed, and the teeth were evaluated using histomorphometric analysis. On histomorphometric analysis, the NO-releasing nanomatrix group demonstrated a significantly lower grade of pulp inflammation (1.00 ± 1.11, mean ± standard devia-tion) compared to the no treatment group (2.21 ± 1.25, p = 0.014). NO-releasing nanomatrix group showed a significantly higher grade of pulp regeneration (2.57 ± 0.85, p = 0.012) and significantly lower grade of pulp inflammation (1.00 ± 0.68, p = 0.025) compared to the no treatment group. In conclusion, NO-releasing nanomatrix gel improved pulp regeneration of replanted teeth, though the sample size of this study was rather small. Within the limits of this study, NO-releasing nanomatrix gel can provide more favorable pulpal regeneration despite replantation.

Original languageEnglish
Article number6041
JournalApplied Sciences (Switzerland)
Volume11
Issue number13
DOIs
Publication statusPublished - 1 Jul 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Avulsion
  • Nanomatrix gel
  • Nitric oxide
  • Pulp regeneration
  • Replantation

Fingerprint

Dive into the research topics of 'Doxycycline-loaded nitric oxide-releasing nanomatrix gel in replanted rat molar on pulp regeneration'. Together they form a unique fingerprint.

Cite this