Doxycycline-loaded nitric oxide-releasing nanomatrix gel in replanted rat molar on pulp regeneration

Kwan Hee Yun; Mi Ja Ko; Yong Kown Chae; Koeun Lee; Ok Hyung Nam; Hyo Seol Lee; Kyounga Cheon; Sung Chul Choi

doi:10.3390/app11136041

Doxycycline-loaded nitric oxide-releasing nanomatrix gel in replanted rat molar on pulp regeneration

Kwan Hee Yun
, Mi Ja Ko
, Yong Kown Chae
, Koeun Lee
, Ok Hyung Nam
, Hyo Seol Lee
, Kyounga Cheon
, Sung Chul Choi

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The aim of the present study was to evaluate the effect of doxycycline-loaded NO-releasing nanomatrix gel on pulp regeneration in replantation of avulsed rat teeth. A total of 28 maxillary first molars extracted from rats were replanted. The rats were divided into two groups based on the use of root surface treatment: doxycycline-loaded NO-releasing nanomatrix group and no treat-ment. Eight weeks after replantation, the rats were sacrificed, and the teeth were evaluated using histomorphometric analysis. On histomorphometric analysis, the NO-releasing nanomatrix group demonstrated a significantly lower grade of pulp inflammation (1.00 ± 1.11, mean ± standard devia-tion) compared to the no treatment group (2.21 ± 1.25, p = 0.014). NO-releasing nanomatrix group showed a significantly higher grade of pulp regeneration (2.57 ± 0.85, p = 0.012) and significantly lower grade of pulp inflammation (1.00 ± 0.68, p = 0.025) compared to the no treatment group. In conclusion, NO-releasing nanomatrix gel improved pulp regeneration of replanted teeth, though the sample size of this study was rather small. Within the limits of this study, NO-releasing nanomatrix gel can provide more favorable pulpal regeneration despite replantation.

Original language	English
Article number	6041
Journal	Applied Sciences (Switzerland)
Volume	11
Issue number	13
DOIs	https://doi.org/10.3390/app11136041
Publication status	Published - 1 Jul 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Avulsion
Nanomatrix gel
Nitric oxide
Pulp regeneration
Replantation

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10.3390/app11136041

Cite this

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title = "Doxycycline-loaded nitric oxide-releasing nanomatrix gel in replanted rat molar on pulp regeneration",

abstract = "The aim of the present study was to evaluate the effect of doxycycline-loaded NO-releasing nanomatrix gel on pulp regeneration in replantation of avulsed rat teeth. A total of 28 maxillary first molars extracted from rats were replanted. The rats were divided into two groups based on the use of root surface treatment: doxycycline-loaded NO-releasing nanomatrix group and no treat-ment. Eight weeks after replantation, the rats were sacrificed, and the teeth were evaluated using histomorphometric analysis. On histomorphometric analysis, the NO-releasing nanomatrix group demonstrated a significantly lower grade of pulp inflammation (1.00 ± 1.11, mean ± standard devia-tion) compared to the no treatment group (2.21 ± 1.25, p = 0.014). NO-releasing nanomatrix group showed a significantly higher grade of pulp regeneration (2.57 ± 0.85, p = 0.012) and significantly lower grade of pulp inflammation (1.00 ± 0.68, p = 0.025) compared to the no treatment group. In conclusion, NO-releasing nanomatrix gel improved pulp regeneration of replanted teeth, though the sample size of this study was rather small. Within the limits of this study, NO-releasing nanomatrix gel can provide more favorable pulpal regeneration despite replantation.",

keywords = "Avulsion, Nanomatrix gel, Nitric oxide, Pulp regeneration, Replantation",

author = "Yun, \{Kwan Hee\} and Ko, \{Mi Ja\} and Chae, \{Yong Kown\} and Koeun Lee and Nam, \{Ok Hyung\} and Lee, \{Hyo Seol\} and Kyounga Cheon and Choi, \{Sung Chul\}",

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doi = "10.3390/app11136041",

language = "English",

volume = "11",

journal = "Applied Sciences (Switzerland)",

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T1 - Doxycycline-loaded nitric oxide-releasing nanomatrix gel in replanted rat molar on pulp regeneration

AU - Yun, Kwan Hee

AU - Ko, Mi Ja

AU - Chae, Yong Kown

AU - Lee, Koeun

AU - Nam, Ok Hyung

AU - Lee, Hyo Seol

AU - Cheon, Kyounga

AU - Choi, Sung Chul

PY - 2021/7/1

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N2 - The aim of the present study was to evaluate the effect of doxycycline-loaded NO-releasing nanomatrix gel on pulp regeneration in replantation of avulsed rat teeth. A total of 28 maxillary first molars extracted from rats were replanted. The rats were divided into two groups based on the use of root surface treatment: doxycycline-loaded NO-releasing nanomatrix group and no treat-ment. Eight weeks after replantation, the rats were sacrificed, and the teeth were evaluated using histomorphometric analysis. On histomorphometric analysis, the NO-releasing nanomatrix group demonstrated a significantly lower grade of pulp inflammation (1.00 ± 1.11, mean ± standard devia-tion) compared to the no treatment group (2.21 ± 1.25, p = 0.014). NO-releasing nanomatrix group showed a significantly higher grade of pulp regeneration (2.57 ± 0.85, p = 0.012) and significantly lower grade of pulp inflammation (1.00 ± 0.68, p = 0.025) compared to the no treatment group. In conclusion, NO-releasing nanomatrix gel improved pulp regeneration of replanted teeth, though the sample size of this study was rather small. Within the limits of this study, NO-releasing nanomatrix gel can provide more favorable pulpal regeneration despite replantation.

AB - The aim of the present study was to evaluate the effect of doxycycline-loaded NO-releasing nanomatrix gel on pulp regeneration in replantation of avulsed rat teeth. A total of 28 maxillary first molars extracted from rats were replanted. The rats were divided into two groups based on the use of root surface treatment: doxycycline-loaded NO-releasing nanomatrix group and no treat-ment. Eight weeks after replantation, the rats were sacrificed, and the teeth were evaluated using histomorphometric analysis. On histomorphometric analysis, the NO-releasing nanomatrix group demonstrated a significantly lower grade of pulp inflammation (1.00 ± 1.11, mean ± standard devia-tion) compared to the no treatment group (2.21 ± 1.25, p = 0.014). NO-releasing nanomatrix group showed a significantly higher grade of pulp regeneration (2.57 ± 0.85, p = 0.012) and significantly lower grade of pulp inflammation (1.00 ± 0.68, p = 0.025) compared to the no treatment group. In conclusion, NO-releasing nanomatrix gel improved pulp regeneration of replanted teeth, though the sample size of this study was rather small. Within the limits of this study, NO-releasing nanomatrix gel can provide more favorable pulpal regeneration despite replantation.

KW - Avulsion

KW - Nanomatrix gel

KW - Nitric oxide

KW - Pulp regeneration

KW - Replantation

UR - https://www.scopus.com/pages/publications/85109620968

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DO - 10.3390/app11136041

M3 - Article

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SN - 2076-3417

VL - 11

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

IS - 13

M1 - 6041

ER -

Doxycycline-loaded nitric oxide-releasing nanomatrix gel in replanted rat molar on pulp regeneration

Abstract

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Keywords

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