TY - GEN
T1 - Drug-loaded cubic micro-chamber made of a biodegradable polymer for bacteria-based drug delivery
AU - Yoo, Hyung Jung
AU - Lee, Sangmin
AU - Ahn, Jae Hyun
AU - Cho, Dong Il
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - In this paper, a novel method of fabricating a drug-loaded, cubic micro-chamber made of biodegradable polymer for bacteria-based drug delivery is presented. A biodegradable polymer, poly-capro-lactone (PCL), is used to fabricate the micro-structure. The biocompatibility of PCL is approved by the Food and Drug Administration in U.S. for use in humans. To fabricate the drug-loaded cubic micro-chamber, laminated PCL films are prepared, and a drug is encapsulated between the films using the inkjet printing method. Generally, PCL cannot easy be micromachined by a conventional photolithography technique. Therefore, an x-ray lithography process is developed to fabricate the cubic structure. The fabrication results indicate that the proposed method is excellent for microfabricating drug-loaded cubic micro-chambers made of the biodegradable PCL polymer for bacteria-based drug delivery.
AB - In this paper, a novel method of fabricating a drug-loaded, cubic micro-chamber made of biodegradable polymer for bacteria-based drug delivery is presented. A biodegradable polymer, poly-capro-lactone (PCL), is used to fabricate the micro-structure. The biocompatibility of PCL is approved by the Food and Drug Administration in U.S. for use in humans. To fabricate the drug-loaded cubic micro-chamber, laminated PCL films are prepared, and a drug is encapsulated between the films using the inkjet printing method. Generally, PCL cannot easy be micromachined by a conventional photolithography technique. Therefore, an x-ray lithography process is developed to fabricate the cubic structure. The fabrication results indicate that the proposed method is excellent for microfabricating drug-loaded cubic micro-chambers made of the biodegradable PCL polymer for bacteria-based drug delivery.
KW - bacteria
KW - biodegradable polymer
KW - drug delivery system
KW - microfabrication
KW - x-ray lithography
UR - https://www.scopus.com/pages/publications/84883103786
U2 - 10.1109/NEMS.2013.6559923
DO - 10.1109/NEMS.2013.6559923
M3 - Conference contribution
AN - SCOPUS:84883103786
SN - 9781467363525
T3 - 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
SP - 1141
EP - 1144
BT - 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
T2 - 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
Y2 - 7 April 2013 through 10 April 2013
ER -