TY - JOUR
T1 - Effect of an extract of Pinus koraiensis leaves, Lycium chinense fruit, and Saururus chinensis (Lour.) Baill. leaves on liver function in excessive drinkers
T2 - A randomized, double-blind, placebo-controlled trial
AU - Park, Ju Hyun
AU - Bok, Min Kyung
AU - Kim, Jieun
AU - Maeng, Sungho
AU - Kim, Sung-Hoon
AU - Jung, Ji Hoon
AU - Lee, Hyo Jung
AU - Lim, Hyunjung
N1 - Funding Information:
This work was supported by “Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ01317001)” for research Rural Development Administration, Republic of Korea.
Funding Information:
N/A. This study was conducted in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines (GCP). The study protocol was approved by the Institutional Review Board of Kyung Hee University Korean Medicine Hospital (KOMCIRB 2018-08-005-001) and registered at the Clinical Research Information Service (CRIS) of the Korea Disease Control and Prevention Agency (KDCA) (Registration Number KCT0005331). All subjects provided written informed consent before the experiment. Funding, This work was supported by ?Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ01317001)? for research Rural Development Administration, Republic of Korea.
Publisher Copyright:
© 2021
PY - 2021/8
Y1 - 2021/8
N2 - Chronic alcohol consumption is a major risk factor for alcoholic liver disease. In this study, we examined the effect of an extract of Pinus koraiensis leaves, Lycium chinense fruit, and Saururus chinensis (Lour.) Baill. leaves (PLC) on liver function in Korean. A randomized, double-blind, placebo-controlled study was performed in 50 excessive drinkers. The subjects were randomly assigned to PLC (n = 25, 2,000 mg/day) or placebo (n = 25) groups. Blood liver enzymes, lipid profiles, and antioxidant enzymes were assessed at baseline and 12 weeks. GGT level significantly decreased in women in the test group compared with the placebo group (-2.50 ± 3.54 U/L vs. 3.80 ± 11.23 U/L, P = 0.006). TC (-13.04 ± 25.65 mg/dL, P = 0.020) and LDL-C (-10.33 ± 24.15 mg/dL, P = 0.047) levels reduced in the test group after 12 weeks. Although PLC, appears the possibility of improving liver function in excessive drinkers, however, a larger scale and long-term intervention study should be performed.
AB - Chronic alcohol consumption is a major risk factor for alcoholic liver disease. In this study, we examined the effect of an extract of Pinus koraiensis leaves, Lycium chinense fruit, and Saururus chinensis (Lour.) Baill. leaves (PLC) on liver function in Korean. A randomized, double-blind, placebo-controlled study was performed in 50 excessive drinkers. The subjects were randomly assigned to PLC (n = 25, 2,000 mg/day) or placebo (n = 25) groups. Blood liver enzymes, lipid profiles, and antioxidant enzymes were assessed at baseline and 12 weeks. GGT level significantly decreased in women in the test group compared with the placebo group (-2.50 ± 3.54 U/L vs. 3.80 ± 11.23 U/L, P = 0.006). TC (-13.04 ± 25.65 mg/dL, P = 0.020) and LDL-C (-10.33 ± 24.15 mg/dL, P = 0.047) levels reduced in the test group after 12 weeks. Although PLC, appears the possibility of improving liver function in excessive drinkers, however, a larger scale and long-term intervention study should be performed.
KW - Alcohol use disorder
KW - Alcoholic liver disease
KW - Fatty liver
KW - Nutritional supplement
KW - Pinus koraiensis
UR - http://www.scopus.com/inward/record.url?scp=85110377700&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2021.104535
DO - 10.1016/j.jff.2021.104535
M3 - Article
AN - SCOPUS:85110377700
SN - 1756-4646
VL - 83
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 104535
ER -
