Effect of astaxanthin on the hepatotoxicity, lipid peroxidation and antioxidative enzymes in the liver of CCl4-treated rats

J. O. Kang; S. J. Kim; H. Kim

doi:10.1358/mf.2001.23.2.627931

Effect of astaxanthin on the hepatotoxicity, lipid peroxidation and antioxidative enzymes in the liver of CCl₄-treated rats

J. O. Kang
, S. J. Kim
, H. Kim

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

Astaxanthin is one of many carotenoids present in marine animals, vegetables and fruits. Since carotenoids are known to have antioxidant properties, we tested to determine if astaxanthin could have protective effects in the CCl₄-treated rat liver by activating the antioxidant system. Astaxanthin blocked the increase of glutamate-oxcalacetate transaminase (GOT) and glutamate-pyruvate transaminase (GTP) activity and thiobarbituric acid reactive substances (TBARS) in response to carbon tetrachloride (CCl₄), while causing an increase in glutathione (GSH) levels and superoxide dismutase (SOD) activities in the CCl₄-treated rat liver. These results suggest that astaxanthin protects liver damage induced by CCl₄ by inhibiting lipid peroxidation and stimulating the cellular antioxidant system.

Original language	English
Pages (from-to)	79-84
Number of pages	6
Journal	Methods and Findings in Experimental and Clinical Pharmacology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1358/mf.2001.23.2.627931
Publication status	Published - 2001

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 14 Life Below Water

Keywords

Antioxidation
Astaxanthin
Lipid peroxidation

Access to Document

10.1358/mf.2001.23.2.627931

Cite this

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title = "Effect of astaxanthin on the hepatotoxicity, lipid peroxidation and antioxidative enzymes in the liver of CCl4-treated rats",

abstract = "Astaxanthin is one of many carotenoids present in marine animals, vegetables and fruits. Since carotenoids are known to have antioxidant properties, we tested to determine if astaxanthin could have protective effects in the CCl4-treated rat liver by activating the antioxidant system. Astaxanthin blocked the increase of glutamate-oxcalacetate transaminase (GOT) and glutamate-pyruvate transaminase (GTP) activity and thiobarbituric acid reactive substances (TBARS) in response to carbon tetrachloride (CCl4), while causing an increase in glutathione (GSH) levels and superoxide dismutase (SOD) activities in the CCl4-treated rat liver. These results suggest that astaxanthin protects liver damage induced by CCl4 by inhibiting lipid peroxidation and stimulating the cellular antioxidant system.",

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AU - Kang, J. O.

AU - Kim, S. J.

AU - Kim, H.

PY - 2001

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AB - Astaxanthin is one of many carotenoids present in marine animals, vegetables and fruits. Since carotenoids are known to have antioxidant properties, we tested to determine if astaxanthin could have protective effects in the CCl4-treated rat liver by activating the antioxidant system. Astaxanthin blocked the increase of glutamate-oxcalacetate transaminase (GOT) and glutamate-pyruvate transaminase (GTP) activity and thiobarbituric acid reactive substances (TBARS) in response to carbon tetrachloride (CCl4), while causing an increase in glutathione (GSH) levels and superoxide dismutase (SOD) activities in the CCl4-treated rat liver. These results suggest that astaxanthin protects liver damage induced by CCl4 by inhibiting lipid peroxidation and stimulating the cellular antioxidant system.

KW - Antioxidation

KW - Astaxanthin

KW - Lipid peroxidation

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DO - 10.1358/mf.2001.23.2.627931

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