Abstract
Bojungikki-tang (BIT) has been widely used to treat patients suffering from chronic fatigue syndrome (CFS). However, its effect has not been yet investigated experimentally. Based upon the clinical presentation of CFS, we hypothesized that cytokines may play a role in the pathogenesis of the disease. We studied the effect of BIT on lipopolysaccharide (LPS)-induced various cytokines production in peripheral blood mononuclear cells (PBMC) of CFS patients. Bojungikki-tang (1 mg/mL) significantly inhibited LPS-induced tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10, transforming growth factor (TGF)-β1 production by 63.55%±0.19%, 55.06%±0.27%, 48.23%±0.48%, 54.09%±0.76%, respectively (P<0.05). Bojungikki-tang showed a slightly lower inhibitory effect of LPS-induced Interferon (IFN)-γ production. These results suggest that BIT may be useful in treating fatigue associated with chronic diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 491-501 |
| Number of pages | 11 |
| Journal | Immunopharmacology and Immunotoxicology |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2003 |
Bibliographical note
Funding Information:This work was supported by Korea Research Foundation Grant (KRF-2001-042-F00118).
Keywords
- Bojungikki-tang
- Chronic fatigue syndrome
- Cytokines
- Lipopolysaccharide
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