Effect of carbon based fillers on properties of Chitosan/PVA/βTCP based composite scaffold for bone tissue engineering

Asif Ali; Saleheen Bano; Ruchir Priyadarshi; Yuvraj Singh Negi

doi:10.1016/j.matpr.2019.04.189

Effect of carbon based fillers on properties of Chitosan/PVA/βTCP based composite scaffold for bone tissue engineering

Asif Ali, Saleheen Bano, Ruchir Priyadarshi, Yuvraj Singh Negi

Research output: Contribution to journal › Conference article › peer-review

18 Citations (Scopus)

Abstract

Bone tissue engineering has been area of substantial research since few decades but still a gap exists when it comes to strength and healing tendency of biomaterials with respect to age group, accidental complications etc. Many researches are yet in progress to design a perfect material for bone regeneration. Our attempt in the present study is to develop a porous hybrid material based on Chitosan(CS)/Polyvinyl Alcohol(PVA)/ Beta Tricalcium Phosphate (β-TCP) composite matrix incorporated with various carbon based fillers i.e. Graphene Oxide(GO, Reduced Graphene Oxide (RGO), Carbon Nanotube(CNT) . Scanning electron microscopy (SEM) results of fabricated scaffolds revealed nearly threefold increase in pore diameter when the concentration of each carbon filler incorporated in CS/PVA/βTCP increased to 1%. Addition of fillers also demonstrated significant mineral depositions on samples when treated with SBF .The Ca/P ratio of deposited minerals on some scaffolds was found near 1.67, the stoichiometric ratio of natural bone apatite .Increase in carbon filler concentration in CS/PVA/βTCP matrix also increased the compressive modulus of scaffold.

Original language	English
Pages (from-to)	173-182
Number of pages	10
Journal	Materials Today: Proceedings
Volume	15
DOIs	https://doi.org/10.1016/j.matpr.2019.04.189
Publication status	Published - 2019
Event	2018 International Conference on BioMaterials, BioEngineering and BioTheranostics, BioMET 2018 - Vellore, India Duration: 24 Jul 2018 → 28 Jul 2018

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd. All rights reserved.

Keywords

Carbon nanotube
Chitosan
Graphene oxide
Poly vinyl alcohol
Reduced graphene oxide
β Tri calcium phosphate

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10.1016/j.matpr.2019.04.189

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title = "Effect of carbon based fillers on properties of Chitosan/PVA/βTCP based composite scaffold for bone tissue engineering",

abstract = "Bone tissue engineering has been area of substantial research since few decades but still a gap exists when it comes to strength and healing tendency of biomaterials with respect to age group, accidental complications etc. Many researches are yet in progress to design a perfect material for bone regeneration. Our attempt in the present study is to develop a porous hybrid material based on Chitosan(CS)/Polyvinyl Alcohol(PVA)/ Beta Tricalcium Phosphate (β-TCP) composite matrix incorporated with various carbon based fillers i.e. Graphene Oxide(GO, Reduced Graphene Oxide (RGO), Carbon Nanotube(CNT) . Scanning electron microscopy (SEM) results of fabricated scaffolds revealed nearly threefold increase in pore diameter when the concentration of each carbon filler incorporated in CS/PVA/βTCP increased to 1%. Addition of fillers also demonstrated significant mineral depositions on samples when treated with SBF .The Ca/P ratio of deposited minerals on some scaffolds was found near 1.67, the stoichiometric ratio of natural bone apatite .Increase in carbon filler concentration in CS/PVA/βTCP matrix also increased the compressive modulus of scaffold.",

keywords = "Carbon nanotube, Chitosan, Graphene oxide, Poly vinyl alcohol, Reduced graphene oxide, β Tri calcium phosphate",

author = "Asif Ali and Saleheen Bano and Ruchir Priyadarshi and Negi, {Yuvraj Singh}",

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AU - Ali, Asif

AU - Bano, Saleheen

AU - Priyadarshi, Ruchir

AU - Negi, Yuvraj Singh

PY - 2019

Y1 - 2019

N2 - Bone tissue engineering has been area of substantial research since few decades but still a gap exists when it comes to strength and healing tendency of biomaterials with respect to age group, accidental complications etc. Many researches are yet in progress to design a perfect material for bone regeneration. Our attempt in the present study is to develop a porous hybrid material based on Chitosan(CS)/Polyvinyl Alcohol(PVA)/ Beta Tricalcium Phosphate (β-TCP) composite matrix incorporated with various carbon based fillers i.e. Graphene Oxide(GO, Reduced Graphene Oxide (RGO), Carbon Nanotube(CNT) . Scanning electron microscopy (SEM) results of fabricated scaffolds revealed nearly threefold increase in pore diameter when the concentration of each carbon filler incorporated in CS/PVA/βTCP increased to 1%. Addition of fillers also demonstrated significant mineral depositions on samples when treated with SBF .The Ca/P ratio of deposited minerals on some scaffolds was found near 1.67, the stoichiometric ratio of natural bone apatite .Increase in carbon filler concentration in CS/PVA/βTCP matrix also increased the compressive modulus of scaffold.

AB - Bone tissue engineering has been area of substantial research since few decades but still a gap exists when it comes to strength and healing tendency of biomaterials with respect to age group, accidental complications etc. Many researches are yet in progress to design a perfect material for bone regeneration. Our attempt in the present study is to develop a porous hybrid material based on Chitosan(CS)/Polyvinyl Alcohol(PVA)/ Beta Tricalcium Phosphate (β-TCP) composite matrix incorporated with various carbon based fillers i.e. Graphene Oxide(GO, Reduced Graphene Oxide (RGO), Carbon Nanotube(CNT) . Scanning electron microscopy (SEM) results of fabricated scaffolds revealed nearly threefold increase in pore diameter when the concentration of each carbon filler incorporated in CS/PVA/βTCP increased to 1%. Addition of fillers also demonstrated significant mineral depositions on samples when treated with SBF .The Ca/P ratio of deposited minerals on some scaffolds was found near 1.67, the stoichiometric ratio of natural bone apatite .Increase in carbon filler concentration in CS/PVA/βTCP matrix also increased the compressive modulus of scaffold.

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KW - Chitosan

KW - Graphene oxide

KW - Poly vinyl alcohol

KW - Reduced graphene oxide

KW - β Tri calcium phosphate

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SN - 2214-7853

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ER -

Effect of carbon based fillers on properties of Chitosan/PVA/βTCP based composite scaffold for bone tissue engineering

Abstract

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Keywords

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