Effect of crotonaldehyde on the induction of COX-2 expression in human endothelial cells

Seung Eun Lee, Hye Rim Park, Hyemi Kim, Yeoum Choi, Young Ho Jin, Cheung Seog Park, Hyun Jong Ahn, Jeong Je Cho, Yong Seek Park

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Cyclooxygenase-2 (COX-2), an inducible isoform protein, regulates diverse biological actions in vascular pathophysiology. COX-2 is induced in response to numerous stimuli, which results in prostaglandin (PG) production related to inflammation. Crotonaldehyde (CRA) is an extremely toxic α, β-unsaturated aldehyde and a major compound found in cigarette smoke. α, β-Unsaturated aldehyde in cigarette smoke is thought to mediate inflammation and vascular dysfunction. In this study, we evaluated the effect of CRA stimulation on COX-2 expression in human umbilical vein endothelial cells. CRA-stimulated COX-2 induction was accompanied by enhanced p38 phosphorylation and PGE2 generation. However, CRA-induced PGE2 production was reduced by pretreatment with an inhibitor of p38 MAPK. These results demonstrated that in human endothelial cells, CRA-induced COX-2-dependent PGE2 generation was mediated by p38 MAPK, and CRA may play a role in the development of inflammation.

Original languageEnglish
Pages (from-to)345-350
Number of pages6
JournalMolecular and Cellular Toxicology
Volume13
Issue number3
DOIs
Publication statusPublished - 1 Sep 2017

Keywords

  • Cigarette smoke
  • Crotonaldehyde
  • Cyclooxygenase-2
  • Endothelial cells
  • Oxidative stress

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