Abstract
A systematic design and miniaturization of conventional clinical and diagnostic tools are emerging in many nanobiotechnology and nanobioscience fields. Recently, the pharmaceutical and biotechnological industries have continuously accelerated novel drug discovery for cellular therapeutics of hard-to-cure diseases. Electroporation is a promising candidate in gene transfection methods for future cellular therapeutics. Here, we report our initial study on the effect of geometry on impedance of cell suspended media in electroporation using a microchannel. A full understanding of the electroporation environment and conditions enabled us to optimize protocols of electroporation for various cell lines efficiently. Furthermore, this study will open up a new vista of future electroporation devices using microstructures.
| Original language | English |
|---|---|
| Pages (from-to) | 696-699 |
| Number of pages | 4 |
| Journal | Current Applied Physics |
| Volume | 8 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Oct 2008 |
Bibliographical note
Funding Information:This work was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (02-PJ10-PG4-PT02-0042) and partly supported by the Brain Korea 21 Project in 2006.
Keywords
- Electroporation
- Impedance
- Microstructure