Abstract
We investigated the effect of Kumhwang-San on anaphylactic reaction. Kumhwang-San dose-dependently inhibited mast cell-mediated systemic anaphylactic reaction induced by compound 48/80. Kumhwang-San significantly inhibited plasma histamine levels induced by compound 48/80. Kumhwang-San dose-dependently inhibited histamine release from the rat peritoneal mast cells activated by compound 48/80 or substance P. The level of cAMP in rat peritoneal mast cells, when Kumhwang-San was added, transiently and significantly increased about 3-fold compared with that of basal cells. These results suggest that Kumhwang-San will be beneficial in the treatment of anaphylactic reaction.
| Original language | English |
|---|---|
| Pages (from-to) | 163-174 |
| Number of pages | 12 |
| Journal | Immunopharmacology and Immunotoxicology |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1999 |
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