This study was performed to investigate the effect of low-energy laser irradiation on extraction socket healing in strptozotocin-induced diabetic rats. 24 male rats(about 12 weeks old) were divided into 4 groups: 1) Extraction and natural healing in normal rat for control group, 2) Extraction and low-energy irradiation therapy in normal rat for experimental group I, 3) Extraction and natural healing in streptozotocin-induced rat for experimental group II, 4) Extraction and low-energy irradiation therapy in streptozotocin-induced rat for experimental group III. The right and left maxillary 1st molars were extracted in all groups. For laser irradiation, we used Nd:YAG laser(50 mJ, 5 Hz) for 1 min(30 sec. irradiation, 30 sec. rest, 30 sec. irradiation) everyday. At 3, 5, 7, 14 days after extraction, rats were sacrificed and the specimens were compared with H&E stained slides. Experimental group I showed the fastest socket wound healing and the most new bone formation. Experimental group II showed the worst socket wound healing. Experimental group III did not show significant difference compared to control group. Laser irradiation groups showed less infiltration of inflammatory cell than normal healing groups. These results suggest that low-energy Nd:YAG laser irradiation could promote the extraction wound healing in streptozotocin-induced diabetic rats.
|Number of pages||9|
|Journal||Tissue Engineering and Regenerative Medicine|
|Publication status||Published - Jun 2009|
- Diabetic rat
- Extraction socket healing
- LLLT(low level laser therapy)
- Nd:YAG laser