Abstract
We performed extracellular potential recording with dissected snail ganglia inside an MRI scanner to investigate correlation between neuronal activity and MR image intensity. To increase neuronal activity we applied a nitric oxide donor, sodium-nitrosocystein, to the ganglia. The MR image intensity change in the ganglia region is correlated with the neuronal activity and was up to 5.49 ± 1.94%. Since the snail has non-magnetic hemocyanins as oxygen carrying protein, it seems that the image intensity change is mainly due to the local magnetic fields produced by the neuronal currents.
| Original language | English |
|---|---|
| Pages (from-to) | 2783-2786 |
| Number of pages | 4 |
| Journal | NeuroReport |
| Volume | 15 |
| Issue number | 18 |
| Publication status | Published - 22 Dec 2004 |
Keywords
- Extracellular potential recording
- Magnetic source MRI
- Neuronal currents
- Nitric oxide
- Snail ganglia
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