Effect of Stewartia koreana Boiling Extract (SKBE) on Osteoarthritis and Purification of Spinasterol From SKBE

Sang Min Lee; Hye Jin Moon; Hong Joon Yoon; Chun Soo Na; Jin Beom Kim; Dae Seung Na; Tae Hoon Lee; Hakwon Kim

doi:10.5012/jkcs.2023.67.2.129

Effect of Stewartia koreana Boiling Extract (SKBE) on Osteoarthritis and Purification of Spinasterol From SKBE

Sang Min Lee, Hye Jin Moon, Hong Joon Yoon, Chun Soo Na, Jin Beom Kim, Dae Seung Na, Tae Hoon Lee, Hakwon Kim

Research output: Contribution to journal › Article › peer-review

Abstract

Osteoarthritis is to the abnormality of the inflammatory response of joint tissue caused by various causes such as aging, and muscle loss. In this study, the activity in joint inflammation was verified using SKBE, a plant extract, and the expression levels of arthritis-inducing proteins including MMP-1, MMP-3, MMP-13, and collagen type II in vitro were compared and analyzed. Furthermore, we synthesized α-spinasterol, an active ingredient of SKBE, by the previously reported synthesis method and these findings could provide a new starting point for the development of treatments for osteoarthritis.

Original language	English
Pages (from-to)	129-136
Number of pages	8
Journal	Journal of the Korean Chemical Society
Volume	67
Issue number	2
DOIs	https://doi.org/10.5012/jkcs.2023.67.2.129
Publication status	Published - 20 Apr 2023

Bibliographical note

Publisher Copyright:
© 2023 Korean Chemical Society. All rights reserved.

Keywords

Active ingredient
Inflammatory
Osteoarthritis
Stewartia koreana boiling extract
α-Spinasterol

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10.5012/jkcs.2023.67.2.129

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abstract = "Osteoarthritis is to the abnormality of the inflammatory response of joint tissue caused by various causes such as aging, and muscle loss. In this study, the activity in joint inflammation was verified using SKBE, a plant extract, and the expression levels of arthritis-inducing proteins including MMP-1, MMP-3, MMP-13, and collagen type II in vitro were compared and analyzed. Furthermore, we synthesized α-spinasterol, an active ingredient of SKBE, by the previously reported synthesis method and these findings could provide a new starting point for the development of treatments for osteoarthritis.",

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AU - Kim, Jin Beom

AU - Na, Dae Seung

AU - Lee, Tae Hoon

AU - Kim, Hakwon

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AB - Osteoarthritis is to the abnormality of the inflammatory response of joint tissue caused by various causes such as aging, and muscle loss. In this study, the activity in joint inflammation was verified using SKBE, a plant extract, and the expression levels of arthritis-inducing proteins including MMP-1, MMP-3, MMP-13, and collagen type II in vitro were compared and analyzed. Furthermore, we synthesized α-spinasterol, an active ingredient of SKBE, by the previously reported synthesis method and these findings could provide a new starting point for the development of treatments for osteoarthritis.

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Effect of Stewartia koreana Boiling Extract (SKBE) on Osteoarthritis and Purification of Spinasterol From SKBE

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Keywords

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