Effect of Vitex rotundifolia on immediate-type allergic reaction

Tae Yong Shin; Sug Hyun Kim; Jong Phil Lim; Eun Sil Suh; Hyun Ja Jeong; Byung Do Kim; Eun Jeung Park; Woo Jun Hwang; Do Gon Rye; Seung Hwa Baek; Nyeon Hyoung An; Hyung Min Kim

doi:10.1016/S0378-8741(00)00258-0

Effect of Vitex rotundifolia on immediate-type allergic reaction

Tae Yong Shin
, Sug Hyun Kim
, Jong Phil Lim
, Eun Sil Suh
, Hyun Ja Jeong
, Byung Do Kim
, Eun Jeung Park
, Woo Jun Hwang
, Do Gon Rye
, Seung Hwa Baek
, Nyeon Hyoung An
, Hyung Min Kim

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

We investigated the effect of aqueous extract of Vitex rotundifolia (L.) (Verbenaceae) fruits (VRFE) on the immediate-type allergic reactions in vivo and in vitro. VRFE (10^-4-1.0 g/kg) dose-dependently inhibited systemic allergic reaction induced by compound 48/80. When VRFE was employed in a systemic allergic reaction test, the plasma histamine levels were reduced in a dose-dependent manner. VRFE (5 x 10^-1 and 1.0 g/kg) inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. VRFE (10^- ³-1.0 mg/ml) also dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80 or anti-DNP IgE. Moreover, VRFE (10^-3 mg/ml) had a significant inhibitory effect on anti-DNP IgE- induced tumor necrosis factor-α production from RPMC. These results suggest that VRFE may be beneficial in the regulation of immediate-type allergic reaction. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	443-450
Number of pages	8
Journal	Journal of Ethnopharmacology
Volume	72
Issue number	3
DOIs	https://doi.org/10.1016/S0378-8741(00)00258-0
Publication status	Published - Oct 2000

Bibliographical note

Funding Information:
This work was supported by Woosuk University in 1999.

Keywords

Compound 48/80
Immediate-type allergic reaction
Passive cutaneous anaphylaxis
Rat peritoneal mast cells
Tumor necrosis factor-α
Vitex rotundifolia fruits

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10.1016/S0378-8741(00)00258-0

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title = "Effect of Vitex rotundifolia on immediate-type allergic reaction",

abstract = "We investigated the effect of aqueous extract of Vitex rotundifolia (L.) (Verbenaceae) fruits (VRFE) on the immediate-type allergic reactions in vivo and in vitro. VRFE (10-4-1.0 g/kg) dose-dependently inhibited systemic allergic reaction induced by compound 48/80. When VRFE was employed in a systemic allergic reaction test, the plasma histamine levels were reduced in a dose-dependent manner. VRFE (5 x 10-1 and 1.0 g/kg) inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. VRFE (10- 3-1.0 mg/ml) also dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80 or anti-DNP IgE. Moreover, VRFE (10-3 mg/ml) had a significant inhibitory effect on anti-DNP IgE- induced tumor necrosis factor-α production from RPMC. These results suggest that VRFE may be beneficial in the regulation of immediate-type allergic reaction. (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Compound 48/80, Immediate-type allergic reaction, Passive cutaneous anaphylaxis, Rat peritoneal mast cells, Tumor necrosis factor-α, Vitex rotundifolia fruits",

author = "Shin, \{Tae Yong\} and Kim, \{Sug Hyun\} and Lim, \{Jong Phil\} and Suh, \{Eun Sil\} and Jeong, \{Hyun Ja\} and Kim, \{Byung Do\} and Park, \{Eun Jeung\} and Hwang, \{Woo Jun\} and Rye, \{Do Gon\} and Baek, \{Seung Hwa\} and An, \{Nyeon Hyoung\} and Kim, \{Hyung Min\}",

note = "Funding Information: This work was supported by Woosuk University in 1999.",

year = "2000",

month = oct,

doi = "10.1016/S0378-8741(00)00258-0",

language = "English",

volume = "72",

pages = "443--450",

journal = "Journal of Ethnopharmacology",

issn = "0378-8741",

publisher = "Elsevier Ireland Ltd",

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AU - Shin, Tae Yong

AU - Kim, Sug Hyun

AU - Lim, Jong Phil

AU - Suh, Eun Sil

AU - Jeong, Hyun Ja

AU - Kim, Byung Do

AU - Park, Eun Jeung

AU - Hwang, Woo Jun

AU - Rye, Do Gon

AU - Baek, Seung Hwa

AU - An, Nyeon Hyoung

AU - Kim, Hyung Min

N1 - Funding Information: This work was supported by Woosuk University in 1999.

PY - 2000/10

Y1 - 2000/10

N2 - We investigated the effect of aqueous extract of Vitex rotundifolia (L.) (Verbenaceae) fruits (VRFE) on the immediate-type allergic reactions in vivo and in vitro. VRFE (10-4-1.0 g/kg) dose-dependently inhibited systemic allergic reaction induced by compound 48/80. When VRFE was employed in a systemic allergic reaction test, the plasma histamine levels were reduced in a dose-dependent manner. VRFE (5 x 10-1 and 1.0 g/kg) inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. VRFE (10- 3-1.0 mg/ml) also dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80 or anti-DNP IgE. Moreover, VRFE (10-3 mg/ml) had a significant inhibitory effect on anti-DNP IgE- induced tumor necrosis factor-α production from RPMC. These results suggest that VRFE may be beneficial in the regulation of immediate-type allergic reaction. (C) 2000 Elsevier Science Ireland Ltd.

AB - We investigated the effect of aqueous extract of Vitex rotundifolia (L.) (Verbenaceae) fruits (VRFE) on the immediate-type allergic reactions in vivo and in vitro. VRFE (10-4-1.0 g/kg) dose-dependently inhibited systemic allergic reaction induced by compound 48/80. When VRFE was employed in a systemic allergic reaction test, the plasma histamine levels were reduced in a dose-dependent manner. VRFE (5 x 10-1 and 1.0 g/kg) inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. VRFE (10- 3-1.0 mg/ml) also dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80 or anti-DNP IgE. Moreover, VRFE (10-3 mg/ml) had a significant inhibitory effect on anti-DNP IgE- induced tumor necrosis factor-α production from RPMC. These results suggest that VRFE may be beneficial in the regulation of immediate-type allergic reaction. (C) 2000 Elsevier Science Ireland Ltd.

KW - Compound 48/80

KW - Immediate-type allergic reaction

KW - Passive cutaneous anaphylaxis

KW - Rat peritoneal mast cells

KW - Tumor necrosis factor-α

KW - Vitex rotundifolia fruits

UR - https://www.scopus.com/pages/publications/0033795971

U2 - 10.1016/S0378-8741(00)00258-0

DO - 10.1016/S0378-8741(00)00258-0

M3 - Article

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VL - 72

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EP - 450

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

IS - 3

ER -

Effect of Vitex rotundifolia on immediate-type allergic reaction

Abstract

Bibliographical note

Keywords

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