Effects of acupuncture in the ischemic model of diabetes mellitus rats

S. Choi; G. J. Lee; C. S. Yin; S. K. Choi; S. W. Kang; S. J. Chae; J. H. Park; K. S. Kim; Y. H. Park; H. K. Park

doi:10.1007/978-3-642-03889-1_141

Effects of acupuncture in the ischemic model of diabetes mellitus rats

S. Choi, G. J. Lee, C. S. Yin, S. K. Choi, S. W. Kang, S. J. Chae, J. H. Park, K. S. Kim, Y. H. Park, H. K. Park

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Acupuncture has been a time honored therapy to be effective for emergency conditions as an ischemic stroke. Glutamate excitotoxicity is seen as the major mechanisms for neuronal death, ischemic injury. An eleven vessel occlusion (11VO) was used as a diabetes mellitus rat model of global ischemia. Changes of the extracellular glutamate releases, cerebral blood flow and electroencephalogram were observed using real time monitoring system with a sampling frequency of 256 Hz and three periods including control of 10 min, occlusion of 10 min and reperfusion of 40 min. Animals were divided into two groups as control and acupuncture. Acupuncture group was stimulated manually with acupunctures on GB34 and GB39 acupuncture sites on both hind limbs during the occlusion period. While reduction level of blood flow during the occlusion period and hyperemia during the reperfusion period was not different between groups, peak concentration of extracellular glutamate levels were significantly lower in the acupuncture group (p < 0.01). This study revealed that acupuncture stimulation showed glutamate moderating effect in such a devastating ischemic condition as 11VO model, which maybe a possible mechanism of acupuncture effect for ischemic stroke.

Original language	English
Title of host publication	World Congress on Medical Physics and Biomedical Engineering
Subtitle of host publication	Neuroengineering, Neural Systems, Rehabilitation and Prosthetics
Publisher	Springer Verlag
Pages	527-528
Number of pages	2
Edition	9
ISBN (Print)	9783642038884
DOIs	https://doi.org/10.1007/978-3-642-03889-1_141
Publication status	Published - 2009
Event	World Congress on Medical Physics and Biomedical Engineering: Neuroengineering, Neural Systems, Rehabilitation and Prosthetics - Munich, Germany Duration: 7 Sept 2009 → 12 Sept 2009

Publication series

Name	IFMBE Proceedings
Number	9
Volume	25
ISSN (Print)	1680-0737

Conference

Conference	World Congress on Medical Physics and Biomedical Engineering: Neuroengineering, Neural Systems, Rehabilitation and Prosthetics
Country/Territory	Germany
City	Munich
Period	7/09/09 → 12/09/09

Keywords

Acupuncture
Cerebral blood flow
Diabetes mellitus
Eleven vessel occlusion
Glutamate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-642-03889-1_141

Cite this

Choi, S., Lee, G. J., Yin, C. S., Choi, S. K., Kang, S. W., Chae, S. J., Park, J. H., Kim, K. S., Park, Y. H., & Park, H. K. (2009). Effects of acupuncture in the ischemic model of diabetes mellitus rats. In World Congress on Medical Physics and Biomedical Engineering: Neuroengineering, Neural Systems, Rehabilitation and Prosthetics (9 ed., pp. 527-528). (IFMBE Proceedings; Vol. 25, No. 9). Springer Verlag. https://doi.org/10.1007/978-3-642-03889-1_141

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title = "Effects of acupuncture in the ischemic model of diabetes mellitus rats",

abstract = "Acupuncture has been a time honored therapy to be effective for emergency conditions as an ischemic stroke. Glutamate excitotoxicity is seen as the major mechanisms for neuronal death, ischemic injury. An eleven vessel occlusion (11VO) was used as a diabetes mellitus rat model of global ischemia. Changes of the extracellular glutamate releases, cerebral blood flow and electroencephalogram were observed using real time monitoring system with a sampling frequency of 256 Hz and three periods including control of 10 min, occlusion of 10 min and reperfusion of 40 min. Animals were divided into two groups as control and acupuncture. Acupuncture group was stimulated manually with acupunctures on GB34 and GB39 acupuncture sites on both hind limbs during the occlusion period. While reduction level of blood flow during the occlusion period and hyperemia during the reperfusion period was not different between groups, peak concentration of extracellular glutamate levels were significantly lower in the acupuncture group (p < 0.01). This study revealed that acupuncture stimulation showed glutamate moderating effect in such a devastating ischemic condition as 11VO model, which maybe a possible mechanism of acupuncture effect for ischemic stroke.",

keywords = "Acupuncture, Cerebral blood flow, Diabetes mellitus, Eleven vessel occlusion, Glutamate",

author = "S. Choi and Lee, {G. J.} and Yin, {C. S.} and Choi, {S. K.} and Kang, {S. W.} and Chae, {S. J.} and Park, {J. H.} and Kim, {K. S.} and Park, {Y. H.} and Park, {H. K.}",

year = "2009",

doi = "10.1007/978-3-642-03889-1_141",

language = "English",

isbn = "9783642038884",

series = "IFMBE Proceedings",

publisher = "Springer Verlag",

number = "9",

pages = "527--528",

booktitle = "World Congress on Medical Physics and Biomedical Engineering",

address = "Germany",

edition = "9",

note = "World Congress on Medical Physics and Biomedical Engineering: Neuroengineering, Neural Systems, Rehabilitation and Prosthetics ; Conference date: 07-09-2009 Through 12-09-2009",

}

Choi, S , Lee, GJ , Yin, CS , Choi, SK, Kang, SW, Chae, SJ, Park, JH, Kim, KS, Park, YH & Park, HK 2009, Effects of acupuncture in the ischemic model of diabetes mellitus rats. in World Congress on Medical Physics and Biomedical Engineering: Neuroengineering, Neural Systems, Rehabilitation and Prosthetics. 9 edn, IFMBE Proceedings, no. 9, vol. 25, Springer Verlag, pp. 527-528, World Congress on Medical Physics and Biomedical Engineering: Neuroengineering, Neural Systems, Rehabilitation and Prosthetics, Munich, Germany, 7/09/09. https://doi.org/10.1007/978-3-642-03889-1_141

Effects of acupuncture in the ischemic model of diabetes mellitus rats. / Choi, S.; Lee, G. J.; Yin, C. S. et al.
World Congress on Medical Physics and Biomedical Engineering: Neuroengineering, Neural Systems, Rehabilitation and Prosthetics. 9. ed. Springer Verlag, 2009. p. 527-528 (IFMBE Proceedings; Vol. 25, No. 9).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Effects of acupuncture in the ischemic model of diabetes mellitus rats

AU - Choi, S.

AU - Lee, G. J.

AU - Yin, C. S.

AU - Choi, S. K.

AU - Kang, S. W.

AU - Chae, S. J.

AU - Park, J. H.

AU - Kim, K. S.

AU - Park, Y. H.

AU - Park, H. K.

PY - 2009

Y1 - 2009

N2 - Acupuncture has been a time honored therapy to be effective for emergency conditions as an ischemic stroke. Glutamate excitotoxicity is seen as the major mechanisms for neuronal death, ischemic injury. An eleven vessel occlusion (11VO) was used as a diabetes mellitus rat model of global ischemia. Changes of the extracellular glutamate releases, cerebral blood flow and electroencephalogram were observed using real time monitoring system with a sampling frequency of 256 Hz and three periods including control of 10 min, occlusion of 10 min and reperfusion of 40 min. Animals were divided into two groups as control and acupuncture. Acupuncture group was stimulated manually with acupunctures on GB34 and GB39 acupuncture sites on both hind limbs during the occlusion period. While reduction level of blood flow during the occlusion period and hyperemia during the reperfusion period was not different between groups, peak concentration of extracellular glutamate levels were significantly lower in the acupuncture group (p < 0.01). This study revealed that acupuncture stimulation showed glutamate moderating effect in such a devastating ischemic condition as 11VO model, which maybe a possible mechanism of acupuncture effect for ischemic stroke.

AB - Acupuncture has been a time honored therapy to be effective for emergency conditions as an ischemic stroke. Glutamate excitotoxicity is seen as the major mechanisms for neuronal death, ischemic injury. An eleven vessel occlusion (11VO) was used as a diabetes mellitus rat model of global ischemia. Changes of the extracellular glutamate releases, cerebral blood flow and electroencephalogram were observed using real time monitoring system with a sampling frequency of 256 Hz and three periods including control of 10 min, occlusion of 10 min and reperfusion of 40 min. Animals were divided into two groups as control and acupuncture. Acupuncture group was stimulated manually with acupunctures on GB34 and GB39 acupuncture sites on both hind limbs during the occlusion period. While reduction level of blood flow during the occlusion period and hyperemia during the reperfusion period was not different between groups, peak concentration of extracellular glutamate levels were significantly lower in the acupuncture group (p < 0.01). This study revealed that acupuncture stimulation showed glutamate moderating effect in such a devastating ischemic condition as 11VO model, which maybe a possible mechanism of acupuncture effect for ischemic stroke.

KW - Acupuncture

KW - Cerebral blood flow

KW - Diabetes mellitus

KW - Eleven vessel occlusion

KW - Glutamate

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U2 - 10.1007/978-3-642-03889-1_141

DO - 10.1007/978-3-642-03889-1_141

M3 - Conference contribution

AN - SCOPUS:77950378573

SN - 9783642038884

T3 - IFMBE Proceedings

SP - 527

EP - 528

BT - World Congress on Medical Physics and Biomedical Engineering

PB - Springer Verlag

T2 - World Congress on Medical Physics and Biomedical Engineering: Neuroengineering, Neural Systems, Rehabilitation and Prosthetics

Y2 - 7 September 2009 through 12 September 2009

ER -

Effects of acupuncture in the ischemic model of diabetes mellitus rats

Abstract

Publication series

Conference

Keywords

UN SDGs

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