Effects of probiotics or broccoli supplementation on helicobacter pylori eradication with standard clarithromycin-based triple therapy

Young Woon Chang, Yoo Min Park, Chi Hyuk Oh, Shin Ju Oh, Jun Hyung Cho, Jung Wook Kim, Jae Young Jang

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Background/Aims: The eradication failure rate of standard triple therapy (proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has increased owing to antibiotic resistance in Korea. We assessed whether Saccharomyces boulardii probiotic or broccoli sprout extract sulforaphane supplementation could increase the H. pylori eradication rate and/or reduce antibiotic-associated adverse events. Methods: A total of 217 patients with H. pylori-positive chronic gastritis or peptic ulcer disease were recruited. Clarithromycin resistance was assessed in all patients by testing for A2142G and A2143G point mutations in H. pylori 23S rRNA using a dual-priming polymerase chain reaction (PCR) oligonucleotide. Thirty-four patients (17.3%) were clarithromycin-resistant and were excluded from the study. Finally, 183 patients with infections not resistant to clarithromycin were randomly assigned to triple therapy only (group A, n = 61), triple therapy plus probiotics (group B, n = 61), or triple therapy plus sulforaphane (group C, n = 61) groups. CYP2C19 polymorphisms were examined at position G681A of exon 5 and G636A of exon 4 by PCR with restriction fragment length polymorphism (PCR-RFLP) analysis. H. pylori eradication was assessed by13C-urea breath test 4 weeks after treatment completion. Results: The eradication rates were similar among the groups both in the intention-to-treat (A = 85.2%, B = 89.6%, and C = 81.6%) and per-protocol (A = 89.2%, B = 86.8%, and C = 96.3%) analyses. The frequencies of overall adverse events in the groups also did not differ (A vs. B: p = 0.574; A vs. C: p = 1.000). Conclusions: Probiotic or sulforaphane with triple therapy for H. pylori infection neither increased the eradication rate nor reduced the occurrence of adverse events.

Original languageEnglish
Pages (from-to)574-581
Number of pages8
JournalKorean Journal of Internal Medicine
Volume35
Issue number3
DOIs
Publication statusPublished - May 2020

Bibliographical note

Publisher Copyright:
© 2020 The Korean Association of Internal Medicine.

Keywords

  • Helicobacter pylori
  • Probiotics
  • Sulforaphane

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