Effects of sinapic acid of 4 vessel occlusion model-induced ischemia and cognitive impairments in the rat

Young Ock Kim; Sang Won Lee; Myung Sook Oh; Hee Jae Lee

doi:10.9758/cpn.2011.9.2.86

Effects of sinapic acid of 4 vessel occlusion model-induced ischemia and cognitive impairments in the rat

Young Ock Kim, Sang Won Lee, Myung Sook Oh, Hee Jae Lee

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

Objective: Sinapic acid (SA, Sinapine), small naturally occurring hydroxycinnamic acid, has a GABA(A) receptor agonistic property and free radical scavenging activity. We examined potential neuroprotective effects of sinapic acid (SA) using global cerebral ischemia animal model Methods: MTT assay was performed to determine cytotoxic effects of SA. To examine the neuroprotective effects of SA, SA was administrated for 14 d before 4-vessel occlusion. Also, to determine whether SA prevents cognitive impairment, Morris water maze was performed Results: In this study, the efficacy of SA for the prevention of neuronal damage and for the reduction of memory impairment was investigated. Conclusion: The results indicate that SA confers significant neuroprotection especially for ischemic hippocampal neurons. Copyright

Original language	English
Pages (from-to)	86-90
Number of pages	5
Journal	Clinical Psychopharmacology and Neuroscience
Volume	9
Issue number	2
DOIs	https://doi.org/10.9758/cpn.2011.9.2.86
Publication status	Published - Aug 2011

Keywords

Hippocampus
Memory
Neuroprotection effect
Sinapic acid

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.9758/cpn.2011.9.2.86

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title = "Effects of sinapic acid of 4 vessel occlusion model-induced ischemia and cognitive impairments in the rat",

abstract = "Objective: Sinapic acid (SA, Sinapine), small naturally occurring hydroxycinnamic acid, has a GABA(A) receptor agonistic property and free radical scavenging activity. We examined potential neuroprotective effects of sinapic acid (SA) using global cerebral ischemia animal model Methods: MTT assay was performed to determine cytotoxic effects of SA. To examine the neuroprotective effects of SA, SA was administrated for 14 d before 4-vessel occlusion. Also, to determine whether SA prevents cognitive impairment, Morris water maze was performed Results: In this study, the efficacy of SA for the prevention of neuronal damage and for the reduction of memory impairment was investigated. Conclusion: The results indicate that SA confers significant neuroprotection especially for ischemic hippocampal neurons. Copyright",

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T1 - Effects of sinapic acid of 4 vessel occlusion model-induced ischemia and cognitive impairments in the rat

AU - Kim, Young Ock

AU - Lee, Sang Won

AU - Oh, Myung Sook

AU - Lee, Hee Jae

PY - 2011/8

Y1 - 2011/8

N2 - Objective: Sinapic acid (SA, Sinapine), small naturally occurring hydroxycinnamic acid, has a GABA(A) receptor agonistic property and free radical scavenging activity. We examined potential neuroprotective effects of sinapic acid (SA) using global cerebral ischemia animal model Methods: MTT assay was performed to determine cytotoxic effects of SA. To examine the neuroprotective effects of SA, SA was administrated for 14 d before 4-vessel occlusion. Also, to determine whether SA prevents cognitive impairment, Morris water maze was performed Results: In this study, the efficacy of SA for the prevention of neuronal damage and for the reduction of memory impairment was investigated. Conclusion: The results indicate that SA confers significant neuroprotection especially for ischemic hippocampal neurons. Copyright

AB - Objective: Sinapic acid (SA, Sinapine), small naturally occurring hydroxycinnamic acid, has a GABA(A) receptor agonistic property and free radical scavenging activity. We examined potential neuroprotective effects of sinapic acid (SA) using global cerebral ischemia animal model Methods: MTT assay was performed to determine cytotoxic effects of SA. To examine the neuroprotective effects of SA, SA was administrated for 14 d before 4-vessel occlusion. Also, to determine whether SA prevents cognitive impairment, Morris water maze was performed Results: In this study, the efficacy of SA for the prevention of neuronal damage and for the reduction of memory impairment was investigated. Conclusion: The results indicate that SA confers significant neuroprotection especially for ischemic hippocampal neurons. Copyright

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KW - Memory

KW - Neuroprotection effect

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DO - 10.9758/cpn.2011.9.2.86

M3 - Review article

AN - SCOPUS:80052603259

SN - 1738-1088

VL - 9

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EP - 90

JO - Clinical Psychopharmacology and Neuroscience

JF - Clinical Psychopharmacology and Neuroscience

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ER -

Effects of sinapic acid of 4 vessel occlusion model-induced ischemia and cognitive impairments in the rat

Abstract

Keywords

UN SDGs

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