Enhanced bone regeneration by porous poly(L-lactide) scaffolds with surface-immobilized nano-hydroxyapatite

Ahn Na Koo, Il Keun Kwon, Sang Cheon Lee, Soon Ki Lee, Hyung Sub Kim, Yi Hyung Woo, Seong Hyun Jeon, Ji Hwa Chae, Ke Won Kang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Novel porous poly(L-lactide) (PLLA) scaffolds with surface-immobilized nano-hydroxyapatite (N-HAp) were synthesized for effective bone regeneration. N-Hap-bearing surface phosphate functionalities were immobilized chemically on the pore surface of amine-treated PLLA scaffolds. Thermogravimetric analysis (TGA) showed that 24 wt% of N-HAp had been immobilized on the scaffold pore surface. Field-emission scanning electron microscopy (FE-SEM) and X-ray photoelectron spectroscopy (XPS) confirmed that N-HAp was exposed markedly on the pore surfaces of scaffolds compared to the conventional scaffold fabricated by a bulk-mixing process of PLLA and N-HAp. The PLLA scaffold with surface-immobilized N-HAp had a higher surface Ca atomic ratio (4.6%) than that on the pore surface of the bulk-mixed PLLA/N-HAp scaffold (Ca = 0.4%). The porous PLLA scaffolds with surface-immobilized N-HAp provided favorable environments for enhanced in vivo bone tissue growth, which was estimated by hematoxylin and eosin (H&E) staining for organic bone tissues and alizarin red S staining for inorganic bone minerals. These results suggest that the N-HAp immobilization approach may produce many useful scaffolds with pore surfaces featuring excellent bone tissue-regenerative properties. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)1030-1036
Number of pages7
JournalMacromolecular Research
Volume18
Issue number10
DOIs
Publication statusPublished - Oct 2010

Keywords

  • bone regeneration
  • hybrid
  • nano-hydroxyapatite
  • poly(L-lactide)
  • porous scaffold

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