Abstract
We studied the effect of the methanol extract of Oryza sativa L. subsp. hsien Ting (OSHT) on anaphylaxis. OSHT (0.001-1.0 mg g-1 body weight (BW)) dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in rats. When OSHT was pretreated at concentrations ranging from 0.001 to 1.0 mg g-1 BW, the serum histamine levels were reduced in a dose-dependent manner. OSHT (0.001-1.0 mg g-1 BW) also inhibited local anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Moreover, OSHT dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The level of cAMP in RPMC, when OSHT was added, significantly increased approx. 20-fold compared with that of basal cells. These results indicate that OSHT possesses strong antianaphylactic activity by inhibition of histamine release from mast cells in vivo and in vitro.
| Original language | English |
|---|---|
| Pages (from-to) | 31-36 |
| Number of pages | 6 |
| Journal | Pharmacological Research |
| Volume | 40 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 1999 |
Bibliographical note
Funding Information:This study is supported by the Oriental Medicine Fund of Ministry of Health and Welfare, Republic of Korea.
Keywords
- Anaphylaxis
- Histamine
- Oryza sativa L. subsp. hsien Ting
- Rat peritoneal mast cells
- cAMP
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