TY - JOUR
T1 - Evolution of buffering in a genetic circuit controlling plant stem cell proliferation
AU - Rodriguez-Leal, Daniel
AU - Xu, Cao
AU - Kwon, Choon Tak
AU - Soyars, Cara
AU - Demesa-Arevalo, Edgar
AU - Man, Jarrett
AU - Liu, Lei
AU - Lemmon, Zachary H.
AU - Jones, Daniel S.
AU - Van Eck, Joyce
AU - Jackson, David P.
AU - Bartlett, Madelaine E.
AU - Nimchuk, Zachary L.
AU - Lippman, Zachary B.
N1 - Publisher Copyright:
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Precise control of plant stem cell proliferation is necessary for the continuous and reproducible development of plant organs 1,2 . The peptide ligand CLAVATA3 (CLV3) and its receptor protein kinase CLAVATA1 (CLV1) maintain stem cell homeostasis within a deeply conserved negative feedback circuit 1,2 . In Arabidopsis, CLV1 paralogs also contribute to homeostasis, by compensating for the loss of CLV1 through transcriptional upregulation 3 . Here, we show that compensation 4,5 operates in diverse lineages for both ligands and receptors, but while the core CLV signaling module is conserved, compensation mechanisms have diversified. Transcriptional compensation between ligand paralogs operates in tomato, facilitated by an ancient gene duplication that impacted the domestication of fruit size. In contrast, we found little evidence for transcriptional compensation between ligands in Arabidopsis and maize, and receptor compensation differs between tomato and Arabidopsis. Our findings show that compensation among ligand and receptor paralogs is critical for stem cell homeostasis, but that diverse genetic mechanisms buffer conserved developmental programs.
AB - Precise control of plant stem cell proliferation is necessary for the continuous and reproducible development of plant organs 1,2 . The peptide ligand CLAVATA3 (CLV3) and its receptor protein kinase CLAVATA1 (CLV1) maintain stem cell homeostasis within a deeply conserved negative feedback circuit 1,2 . In Arabidopsis, CLV1 paralogs also contribute to homeostasis, by compensating for the loss of CLV1 through transcriptional upregulation 3 . Here, we show that compensation 4,5 operates in diverse lineages for both ligands and receptors, but while the core CLV signaling module is conserved, compensation mechanisms have diversified. Transcriptional compensation between ligand paralogs operates in tomato, facilitated by an ancient gene duplication that impacted the domestication of fruit size. In contrast, we found little evidence for transcriptional compensation between ligands in Arabidopsis and maize, and receptor compensation differs between tomato and Arabidopsis. Our findings show that compensation among ligand and receptor paralogs is critical for stem cell homeostasis, but that diverse genetic mechanisms buffer conserved developmental programs.
UR - http://www.scopus.com/inward/record.url?scp=85064562166&partnerID=8YFLogxK
U2 - 10.1038/s41588-019-0389-8
DO - 10.1038/s41588-019-0389-8
M3 - Letter
C2 - 30988512
AN - SCOPUS:85064562166
SN - 1061-4036
VL - 51
SP - 786
EP - 792
JO - Nature Genetics
JF - Nature Genetics
IS - 5
ER -