TY - JOUR
T1 - Extracellular Vesicle Nanoarchitectonics for Novel Drug Delivery Applications
AU - Sharma, Shayna
AU - Masud, Mostafa Kamal
AU - Kaneti, Yusuf Valentino
AU - Rewatkar, Prarthana
AU - Koradia, Aayushi
AU - Hossain, Md Shahriar A.
AU - Yamauchi, Yusuke
AU - Popat, Amirali
AU - Salomon, Carlos
N1 - Publisher Copyright:
© 2021 Wiley-VCH GmbH.
PY - 2021/10/21
Y1 - 2021/10/21
N2 - Extracellular vesicles (EVs) can transfer intercellular messages in various (patho)physiological processes and transport biomolecules to recipient cells. EVs possess the capacity to evade the immune system and remain stable over long periods, identifying them as natural carriers for drugs and biologics. However, the challenges associated with EVs isolation, heterogeneity, coexistence with homologous biomolecules, and lack of site-specific delivery, have impeded their potential. In recent years, the amalgamation of EVs with rationally engineered nanostructures has been proposed for achieving effective drug loading and site-specific delivery. With the advancement of nanotechnology and nanoarchitectonics, different nanostructures with tunable size, shapes, and surface properties can be integrated with EVs for drug loading, target binding, efficient delivery, and therapeutics. Such integration may enable improved cellular targeting and the protection of encapsulated drugs for enhanced and specific delivery to target cells. This review summarizes the recent development of nanostructure amalgamated EVs for drug delivery, therapeutics, and real-time monitoring of disease progression. With a specific focus on the exosomal cargo, diverse drug delivery system, and biomimetic nanostructures based on EVs for selective drug delivery, this review also chronicles the needs and challenges of EV-based biomimetic nanostructures and provides a future outlook on the strategies posed.
AB - Extracellular vesicles (EVs) can transfer intercellular messages in various (patho)physiological processes and transport biomolecules to recipient cells. EVs possess the capacity to evade the immune system and remain stable over long periods, identifying them as natural carriers for drugs and biologics. However, the challenges associated with EVs isolation, heterogeneity, coexistence with homologous biomolecules, and lack of site-specific delivery, have impeded their potential. In recent years, the amalgamation of EVs with rationally engineered nanostructures has been proposed for achieving effective drug loading and site-specific delivery. With the advancement of nanotechnology and nanoarchitectonics, different nanostructures with tunable size, shapes, and surface properties can be integrated with EVs for drug loading, target binding, efficient delivery, and therapeutics. Such integration may enable improved cellular targeting and the protection of encapsulated drugs for enhanced and specific delivery to target cells. This review summarizes the recent development of nanostructure amalgamated EVs for drug delivery, therapeutics, and real-time monitoring of disease progression. With a specific focus on the exosomal cargo, diverse drug delivery system, and biomimetic nanostructures based on EVs for selective drug delivery, this review also chronicles the needs and challenges of EV-based biomimetic nanostructures and provides a future outlook on the strategies posed.
KW - biomimetic nanostructures
KW - drug delivery system
KW - exosomes
KW - extracellular vesicles (EVs)
KW - nanoarchitectonics
KW - nanomedicine
UR - http://www.scopus.com/inward/record.url?scp=85109091620&partnerID=8YFLogxK
U2 - 10.1002/smll.202102220
DO - 10.1002/smll.202102220
M3 - Review article
AN - SCOPUS:85109091620
SN - 1613-6810
VL - 17
JO - Small
JF - Small
IS - 42
M1 - 2102220
ER -