Factors associated with a strong response to the T-SPOT.TB in patients with extrapulmonary tuberculosis

Yu Mi Lee; Sun Mi Kim; Su Jin Park; Sang Oh Lee; Sang Ho Choi; Yang Soo Kim; Jun Hee Woo; Sung Han Kim

doi:10.3947/ic.2014.46.4.248

Factors associated with a strong response to the T-SPOT.TB in patients with extrapulmonary tuberculosis

Yu Mi Lee
, Sun Mi Kim
, Su Jin Park
, Sang Oh Lee
, Sang Ho Choi
, Yang Soo Kim
, Jun Hee Woo
, Sung Han Kim

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Limited data are available on which factors are associated with strong immunologic responses to T-SPOT.TB. We investigated the factors associated with strong positive responses in patients with extrapulmonary tuberculosis (E-TB). Of 173 patients with E-TB who gave positive results on T-SPOT.TB, 26 (15%) with a strong positive response (defined as ≥1,000 spot-forming units (SFU)/2.5×10⁵ PBMC to ESAT-6 or CFP-10) and 71 (41%) with a low positive response (≤ 99 SFU (6-99 SFU)/2.5×10⁵ PBMC) were further analyzed. Miliary TB was independently associated with a strong positive response to T-SPOT.TB, while advanced age and immunosuppression were independently associated with weak positive T-SPOT.TB responses.

Original language	English
Pages (from-to)	248-252
Number of pages	5
Journal	Infection and Chemotherapy
Volume	46
Issue number	4
DOIs	https://doi.org/10.3947/ic.2014.46.4.248
Publication status	Published - 2014

Bibliographical note

Publisher Copyright:
© 2014 by The Korean Society of Infectious Diseases|Korean Society for Chemotherapy.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Interferon-gamma release assay
Miliary
Tuberculosis

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10.3947/ic.2014.46.4.248

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title = "Factors associated with a strong response to the T-SPOT.TB in patients with extrapulmonary tuberculosis",

abstract = "Limited data are available on which factors are associated with strong immunologic responses to T-SPOT.TB. We investigated the factors associated with strong positive responses in patients with extrapulmonary tuberculosis (E-TB). Of 173 patients with E-TB who gave positive results on T-SPOT.TB, 26 (15\%) with a strong positive response (defined as ≥1,000 spot-forming units (SFU)/2.5×105 PBMC to ESAT-6 or CFP-10) and 71 (41\%) with a low positive response (≤ 99 SFU (6-99 SFU)/2.5×105 PBMC) were further analyzed. Miliary TB was independently associated with a strong positive response to T-SPOT.TB, while advanced age and immunosuppression were independently associated with weak positive T-SPOT.TB responses.",

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year = "2014",

doi = "10.3947/ic.2014.46.4.248",

language = "English",

volume = "46",

pages = "248--252",

journal = "Infection and Chemotherapy",

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T1 - Factors associated with a strong response to the T-SPOT.TB in patients with extrapulmonary tuberculosis

AU - Lee, Yu Mi

AU - Kim, Sun Mi

AU - Park, Su Jin

AU - Lee, Sang Oh

AU - Choi, Sang Ho

AU - Kim, Yang Soo

AU - Woo, Jun Hee

AU - Kim, Sung Han

PY - 2014

Y1 - 2014

N2 - Limited data are available on which factors are associated with strong immunologic responses to T-SPOT.TB. We investigated the factors associated with strong positive responses in patients with extrapulmonary tuberculosis (E-TB). Of 173 patients with E-TB who gave positive results on T-SPOT.TB, 26 (15%) with a strong positive response (defined as ≥1,000 spot-forming units (SFU)/2.5×105 PBMC to ESAT-6 or CFP-10) and 71 (41%) with a low positive response (≤ 99 SFU (6-99 SFU)/2.5×105 PBMC) were further analyzed. Miliary TB was independently associated with a strong positive response to T-SPOT.TB, while advanced age and immunosuppression were independently associated with weak positive T-SPOT.TB responses.

AB - Limited data are available on which factors are associated with strong immunologic responses to T-SPOT.TB. We investigated the factors associated with strong positive responses in patients with extrapulmonary tuberculosis (E-TB). Of 173 patients with E-TB who gave positive results on T-SPOT.TB, 26 (15%) with a strong positive response (defined as ≥1,000 spot-forming units (SFU)/2.5×105 PBMC to ESAT-6 or CFP-10) and 71 (41%) with a low positive response (≤ 99 SFU (6-99 SFU)/2.5×105 PBMC) were further analyzed. Miliary TB was independently associated with a strong positive response to T-SPOT.TB, while advanced age and immunosuppression were independently associated with weak positive T-SPOT.TB responses.

KW - Interferon-gamma release assay

KW - Miliary

KW - Tuberculosis

UR - https://www.scopus.com/pages/publications/84931305903

U2 - 10.3947/ic.2014.46.4.248

DO - 10.3947/ic.2014.46.4.248

M3 - Article

AN - SCOPUS:84931305903

SN - 2093-2340

VL - 46

SP - 248

EP - 252

JO - Infection and Chemotherapy

JF - Infection and Chemotherapy

IS - 4

ER -

Factors associated with a strong response to the T-SPOT.TB in patients with extrapulmonary tuberculosis

Abstract

Bibliographical note

UN SDGs

Keywords

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