Fret phenomenon on the graphene oxide sheet to detect the specific DNA-DNA hybridization interaction

Fei Liu, Jong Young Choi, Tae Seok Seo

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this study, we explored a potential of graphene oxide (GO) sheets as a fluorescence probe for biological applications. The properties of water-solubility due to the hydrophilic functional groups on the surface and the unique fluorescence emission signal at 546 nm allow the graphene oxide sheets to be used for detecting specific DNA-DNA hybridization event. The fluorescence intensity of GO that is linked with a probe DNA is reduced drastically when the probe is hybridized with a gold nanoparticle (Au NP) labeled target DNA by FRET phenomenon between GO and Au NP.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages210-212
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 1 Nov 20095 Nov 2009

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
Country/TerritoryKorea, Republic of
CityJeju
Period1/11/095/11/09

Keywords

  • DNA hybridization
  • Föster resonance energy transfer (FRET)
  • Graphene oxide

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