Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury

Joo Il Kim; Sang Wook Park; Jhong Jae Lim; Se Il Sohn; Ji Su Shin; Sang Cheol Park; Young Pyo Jang; Eun Kyoung Chung; Hong Woo Lee; Kyung Tae Lee

doi:10.1515/acph-2017-0037

Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury

Joo Il Kim, Sang Wook Park, Jhong Jae Lim, Se Il Sohn, Ji Su Shin, Sang Cheol Park, Young Pyo Jang, Eun Kyoung Chung, Hong Woo Lee, Kyung Tae Lee

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol/HCl- or indomethacin- treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. The optimized floating tablet, IPAP-FR, floated on medium surface with more sustained eupatilin release compared to the non-floating control tablet. X-ray photographs in beagle dogs showed that IPAPFR was retained for > 2 h in the stomach. In the ethanol-induced gastric ulcer rat model, the gastric hemorrhagic lesion was improved more substantially with IPAP-FR compared to the non-floating control tablet. Based on these data, our data suggest that IPAP-FR has an improved therapeutic potential for the treatment of gastric ulcer.

Original language	English
Pages (from-to)	479-494
Number of pages	16
Journal	Acta Pharmaceutica
Volume	67
Issue number	4
DOIs	https://doi.org/10.1515/acph-2017-0037
Publication status	Published - 20 Dec 2017

Bibliographical note

Publisher Copyright:
© by Kyung-Tae Lee 2018.

Keywords

Artemisia princeps Pamp.
Xray photographs
antiulcer
eupatilin
floating drug delivery system

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title = "Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury",

abstract = "In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol/HCl- or indomethacin- treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. The optimized floating tablet, IPAP-FR, floated on medium surface with more sustained eupatilin release compared to the non-floating control tablet. X-ray photographs in beagle dogs showed that IPAPFR was retained for > 2 h in the stomach. In the ethanol-induced gastric ulcer rat model, the gastric hemorrhagic lesion was improved more substantially with IPAP-FR compared to the non-floating control tablet. Based on these data, our data suggest that IPAP-FR has an improved therapeutic potential for the treatment of gastric ulcer.",

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AU - Sohn, Se Il

AU - Shin, Ji Su

AU - Park, Sang Cheol

AU - Jang, Young Pyo

AU - Chung, Eun Kyoung

AU - Lee, Hong Woo

AU - Lee, Kyung Tae

N1 - Publisher Copyright: © by Kyung-Tae Lee 2018.

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AB - In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol/HCl- or indomethacin- treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. The optimized floating tablet, IPAP-FR, floated on medium surface with more sustained eupatilin release compared to the non-floating control tablet. X-ray photographs in beagle dogs showed that IPAPFR was retained for > 2 h in the stomach. In the ethanol-induced gastric ulcer rat model, the gastric hemorrhagic lesion was improved more substantially with IPAP-FR compared to the non-floating control tablet. Based on these data, our data suggest that IPAP-FR has an improved therapeutic potential for the treatment of gastric ulcer.

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Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury

Abstract

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Keywords

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