Generation of an induced pluripotent stem cell line (PNUYHi002-A) from a patient with Alzheimer's disease carrying PRNP M232R variant

Mi Kyoung Kim; Yoon Kim; Nayeon Lee; Hye Ji Moon; Jae Hyeok Lee; Eun Joo Kim; Yong Jun Kim; Jae Ho Kim; Na Yeon Jung

doi:10.1016/j.scr.2024.103361

Generation of an induced pluripotent stem cell line (PNUYHi002-A) from a patient with Alzheimer's disease carrying PRNP M232R variant

Mi Kyoung Kim
, Yoon Kim
, Nayeon Lee
, Hye Ji Moon
, Jae Hyeok Lee
, Eun Joo Kim
, Yong Jun Kim
, Jae Ho Kim
, Na Yeon Jung

Research output: Contribution to journal › Article › peer-review

Abstract

We generated a human induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells isolated from a 59-year-old male patient with Alzheimer's disease (AD). The iPSC line was meticulously characterized to confirm its pluripotency, absence of transgenes, and normal karyotype. The unexpected discovery of the M232R variant in PRNP makes this cell line a valuable resource for investigating AD pathogenesis.

Original language	English
Article number	103361
Journal	Stem Cell Research
Volume	76
DOIs	https://doi.org/10.1016/j.scr.2024.103361
Publication status	Published - Apr 2024

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Publisher Copyright:
© 2024 The Authors

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.scr.2024.103361

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title = "Generation of an induced pluripotent stem cell line (PNUYHi002-A) from a patient with Alzheimer's disease carrying PRNP M232R variant",

abstract = "We generated a human induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells isolated from a 59-year-old male patient with Alzheimer's disease (AD). The iPSC line was meticulously characterized to confirm its pluripotency, absence of transgenes, and normal karyotype. The unexpected discovery of the M232R variant in PRNP makes this cell line a valuable resource for investigating AD pathogenesis.",

author = "Kim, \{Mi Kyoung\} and Yoon Kim and Nayeon Lee and Moon, \{Hye Ji\} and Lee, \{Jae Hyeok\} and Kim, \{Eun Joo\} and Kim, \{Yong Jun\} and Kim, \{Jae Ho\} and Jung, \{Na Yeon\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

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doi = "10.1016/j.scr.2024.103361",

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journal = "Stem Cell Research",

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AU - Kim, Mi Kyoung

AU - Kim, Yoon

AU - Lee, Nayeon

AU - Moon, Hye Ji

AU - Lee, Jae Hyeok

AU - Kim, Eun Joo

AU - Kim, Yong Jun

AU - Kim, Jae Ho

AU - Jung, Na Yeon

PY - 2024/4

Y1 - 2024/4

N2 - We generated a human induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells isolated from a 59-year-old male patient with Alzheimer's disease (AD). The iPSC line was meticulously characterized to confirm its pluripotency, absence of transgenes, and normal karyotype. The unexpected discovery of the M232R variant in PRNP makes this cell line a valuable resource for investigating AD pathogenesis.

AB - We generated a human induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells isolated from a 59-year-old male patient with Alzheimer's disease (AD). The iPSC line was meticulously characterized to confirm its pluripotency, absence of transgenes, and normal karyotype. The unexpected discovery of the M232R variant in PRNP makes this cell line a valuable resource for investigating AD pathogenesis.

UR - https://www.scopus.com/pages/publications/85186348208

U2 - 10.1016/j.scr.2024.103361

DO - 10.1016/j.scr.2024.103361

M3 - Article

C2 - 38437769

AN - SCOPUS:85186348208

SN - 1873-5061

VL - 76

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 103361

ER -

Generation of an induced pluripotent stem cell line (PNUYHi002-A) from a patient with Alzheimer's disease carrying PRNP M232R variant

Abstract

Bibliographical note

UN SDGs

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