Ginger (Zingiber officinale Roscoe), Lemon (Citrus limon L.) Juices as Preventive Agents from Chronic Liver Damage Induced by CCl4: A Biochemical and Histological Study

Oussama Bekkouch, Mohammed Dalli, Mohamed Harnafi, Ilham Touiss, Imane Mokhtari, Soufiane El Assri, Hicham Harnafi, Mohammed Choukri, Seok Jae Ko, Bonglee Kim, Souliman Amrani

Research output: Contribution to journalArticlepeer-review

Abstract

Zingiber officinale Roscoe and Citrus limon L. are well known for their multi-use and for their pharmacological effect in the treatment of many illnesses. This study aims to investigate the chemical composition of the ginger and lemon juice extracts and in addition, to evaluate their antioxidant properties and their hepatoprotective effect against the liver damage of Wistar rats induced by the injection of CCl4 to treated animals. The obtained effects were completed by a histological study for better confirmation of the registered pharmacological effects. The ginger juice extract was found to be rich in 4-gingerol, 6-gingediol, and 6-gingerol, while the lemon juice extract chemical composition was highlighted by the presence of eriodyctiol, rutin, hesperidin, and isorhamnetin. Concerning the antioxidant activity, the ginger, lemon juice extracts, and their formulation showed an important antioxidant potential using TAC (total antioxidant capacity), an antiradical activity against the radical DPPH• (2,2-diphenyl-1-picrylhydrazil), and a ferric reducing power. Finally, the ginger, lemon, and their formulation at different doses were able to prevent CCl4 induced liver damage. Indeed, these different bioactive compounds could be used as alternative agents for the treatment of chronic liver diseases.

Original languageEnglish
Article number390
JournalAntioxidants
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 2022

Keywords

  • Antioxidant
  • CCl4
  • Citrus limon
  • Hepatoprotection
  • Liver damage
  • Synergy
  • Zingiber officinale

Fingerprint

Dive into the research topics of 'Ginger (Zingiber officinale Roscoe), Lemon (Citrus limon L.) Juices as Preventive Agents from Chronic Liver Damage Induced by CCl4: A Biochemical and Histological Study'. Together they form a unique fingerprint.

Cite this