Abstract
In the present study, we examined the effects of ginsenoside Re (Re) on cytokine expression, cytokine-dependent autophagy and cell survival in human CD4+ T cells. When CD4+ T cells isolated from human peripheral blood were treated with Re, LC3 and monodansylcadaverine (MDC), representative markers of autophagy, were decreased in a dose-dependent manner. Interestingly, Re suppressed the production of interferon-gamma (IFN-γ) and immunity-related GTPase family M (IRGM) in CD4+ T cells whereas no changes in other autophagy-related signaling molecules (ERK, p38 and AKT-mTOR-p70S6k) were found. Concomitantly, we observed that Re increased the proliferation of CD4+ T cells with decreased cell death. Our results demonstrate that ginsenoside Re enhanced viability of CD4+ T cells through the regulation of IFN-γ-dependent autophagy activity.
| Original language | English |
|---|---|
| Pages (from-to) | 626-631 |
| Number of pages | 6 |
| Journal | International Immunopharmacology |
| Volume | 10 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2010 |
Bibliographical note
Funding Information:This work was supported by KGCMVP for Technology Development Program of Agriculture and Forestry, Ministry of Agriculture and Forestry and the Biogreen 21 program ( 2008-0401 034054 ), Rural Development Administration, Republic of Korea. We thank the National Instrumentation Center for Environmental Management (NICEM) for immunostaining and flow cytometry analysis. The authors thank the Center for Agricultural Biomaterials, Seoul National University, Republic of Korea for supporting experimental facilities.
Keywords
- Autophagy
- CD4 T cells
- Ginsenoside Re
- Interferon related GTPase family M
- Interferon-gamma
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