Global transcriptional regulator TrmB family members in prokaryotes

Minwook Kim, Soyoung Park, Sung Jae Lee

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


Members of the TrmB family act as global transcriptional regulators for the activation or repression of sugar ABC transporters and central sugar metabolic pathways, including glycolytic, gluconeogenic, and other metabolic pathways, and also as chromosomal stabilizers in archaea. As a relatively newly classified transcriptional regulator family, there is limited experimental evidence for their role in Thermococcales, halophilic archaeon Halobacterium salinarum NRC1, and crenarchaea Sulfolobus strains, despite being one of the extending protein families in archaea. Recently, the protein structures of Pyrococcus furiosus TrmB and TrmBL2 were solved, and the transcriptomic data uncovered by microarray and ChIP-Seq were published. In the present review, recent evidence of the functional roles of TrmB family members in archaea is explained and extended to bacteria.

Original languageEnglish
Pages (from-to)639-645
Number of pages7
JournalJournal of Microbiology
Issue number10
Publication statusPublished - 1 Oct 2016


  • TrmB family members
  • extremophile
  • global transcriptional regulator
  • prokaryote
  • sugar-binding motif


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