GLTSCR2 contributes to the death resistance and invasiveness of hypoxia-selected cancer cells

Jee Youn Kim; Jae Hoon Park; Sun Lee

doi:10.1016/j.febslet.2012.07.064

GLTSCR2 contributes to the death resistance and invasiveness of hypoxia-selected cancer cells

Jee Youn Kim
, Jae Hoon Park
, Sun Lee

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Tumor hypoxia may be an indicator of poor survival in cancer patients. Thus, an understanding of the molecular mechanism responsible for hypoxic tumor selection is essential to gain further insight into tumor biology. Our aim in this study was to investigate whether hypoxia-responsive GLTSCR2 contributes to death resistance and increased invasiveness of hypoxia-selected glioblastoma cells. We found that repeated hypoxia downregulates p53-upstream regulator, GLTSCR2, which resulted in increased death resistance and invasive potential of glioblastoma cells. Restoration of GLTSCR2 expression suppressed the malignant potential of hypoxia-selected cells. Our results indicate that GLTSCR2 participates in hypoxia-induced malignant potential.

Original language	English
Pages (from-to)	3435-3440
Number of pages	6
Journal	FEBS Letters
Volume	586
Issue number	19
DOIs	https://doi.org/10.1016/j.febslet.2012.07.064
Publication status	Published - 21 Sept 2012

Bibliographical note

Funding Information:
This research was supported by the Kyung Hee University Research Fund in 2011 (KHU-20100136). This work was performed during the Sabbatical year (2011) of Lee S.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

GLTSCR2
Glioblastoma
Hypoxia
Pict-1
Tumor resistance

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10.1016/j.febslet.2012.07.064

Cite this

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title = "GLTSCR2 contributes to the death resistance and invasiveness of hypoxia-selected cancer cells",

abstract = "Tumor hypoxia may be an indicator of poor survival in cancer patients. Thus, an understanding of the molecular mechanism responsible for hypoxic tumor selection is essential to gain further insight into tumor biology. Our aim in this study was to investigate whether hypoxia-responsive GLTSCR2 contributes to death resistance and increased invasiveness of hypoxia-selected glioblastoma cells. We found that repeated hypoxia downregulates p53-upstream regulator, GLTSCR2, which resulted in increased death resistance and invasive potential of glioblastoma cells. Restoration of GLTSCR2 expression suppressed the malignant potential of hypoxia-selected cells. Our results indicate that GLTSCR2 participates in hypoxia-induced malignant potential.",

keywords = "GLTSCR2, Glioblastoma, Hypoxia, Pict-1, Tumor resistance",

author = "Kim, \{Jee Youn\} and Park, \{Jae Hoon\} and Sun Lee",

note = "Funding Information: This research was supported by the Kyung Hee University Research Fund in 2011 (KHU-20100136). This work was performed during the Sabbatical year (2011) of Lee S. ",

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doi = "10.1016/j.febslet.2012.07.064",

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T1 - GLTSCR2 contributes to the death resistance and invasiveness of hypoxia-selected cancer cells

AU - Kim, Jee Youn

AU - Park, Jae Hoon

AU - Lee, Sun

N1 - Funding Information: This research was supported by the Kyung Hee University Research Fund in 2011 (KHU-20100136). This work was performed during the Sabbatical year (2011) of Lee S.

PY - 2012/9/21

Y1 - 2012/9/21

N2 - Tumor hypoxia may be an indicator of poor survival in cancer patients. Thus, an understanding of the molecular mechanism responsible for hypoxic tumor selection is essential to gain further insight into tumor biology. Our aim in this study was to investigate whether hypoxia-responsive GLTSCR2 contributes to death resistance and increased invasiveness of hypoxia-selected glioblastoma cells. We found that repeated hypoxia downregulates p53-upstream regulator, GLTSCR2, which resulted in increased death resistance and invasive potential of glioblastoma cells. Restoration of GLTSCR2 expression suppressed the malignant potential of hypoxia-selected cells. Our results indicate that GLTSCR2 participates in hypoxia-induced malignant potential.

AB - Tumor hypoxia may be an indicator of poor survival in cancer patients. Thus, an understanding of the molecular mechanism responsible for hypoxic tumor selection is essential to gain further insight into tumor biology. Our aim in this study was to investigate whether hypoxia-responsive GLTSCR2 contributes to death resistance and increased invasiveness of hypoxia-selected glioblastoma cells. We found that repeated hypoxia downregulates p53-upstream regulator, GLTSCR2, which resulted in increased death resistance and invasive potential of glioblastoma cells. Restoration of GLTSCR2 expression suppressed the malignant potential of hypoxia-selected cells. Our results indicate that GLTSCR2 participates in hypoxia-induced malignant potential.

KW - GLTSCR2

KW - Glioblastoma

KW - Hypoxia

KW - Pict-1

KW - Tumor resistance

UR - https://www.scopus.com/pages/publications/84866610435

U2 - 10.1016/j.febslet.2012.07.064

DO - 10.1016/j.febslet.2012.07.064

M3 - Article

C2 - 22850112

AN - SCOPUS:84866610435

SN - 0014-5793

VL - 586

SP - 3435

EP - 3440

JO - FEBS Letters

JF - FEBS Letters

IS - 19

ER -

GLTSCR2 contributes to the death resistance and invasiveness of hypoxia-selected cancer cells

Abstract

Bibliographical note

UN SDGs

Keywords

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