GLUCOSE-MONITORING JANUS HYDROGEL MICROBEADS WITH COMPENSATION FUNCIONS FOR SURROUNDING PH ENVIRONMENT

This paper presents Janus microbeads for continuous fluorescent glucose monitoring with pH calibration. By using an UV- assisted centrifugal microfluidic device, the Janus hydrogel microbeads that consist of glucose sensor and pH sensor are easily fabricated. The microbead can calibrate the pH values of its surroundings and enables accurate measurements of glucose among various pH conditions. As a proof of concept, an accurate measurement of glucose concentration in the body-fluid-like solution using fluorescent intensities from glucose and pH sensor in microbeads was demonstrated. We believe that our fluorescent microbeads, with pH-calibration capacity, could be applied to fully implantable sensors for continuous glucose monitoring for diabetics.