Hemistepsins with cytotoxic activity from Hemisteptia lyrata

Dae Sik Jang; Min Suk Yang; Tae Joung Ha; Ki Hun Park

doi:10.1055/s-2006-960863

Hemistepsins with cytotoxic activity from Hemisteptia lyrata

Dae Sik Jang
, Min Suk Yang
, Tae Joung Ha
, Ki Hun Park

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Two sesquiterpene lactones were isolated from Hemisteptia lyrata Bunge (Compositae). Their structures were elucidated by spectroscopic methods as recently known hemistepsin and the new 6-O-(2-methylpropenoyl)-3-hydroxy- 4(15), 10(14),11(13)-guaiatrien-12,8-olide. The two hemistepsin derivatives were examined for their in vitro cytotoxic activity against human cell lines such as UACC 62, HCT 15, UO-31, PC-3 and A549. Growth inhibitory property was determined by in vitro treatment of the respective cell lines using the sulforhodamine B assay (SRB). Both compounds exhibited significant cytotoxic activity (IC₅₀ < 4.3 μg/ml) on all five human cell lines tested.

Original language	English
Pages (from-to)	765-766
Number of pages	2
Journal	Planta Medica
Volume	65
Issue number	8
DOIs	https://doi.org/10.1055/s-2006-960863
Publication status	Published - Dec 1999

Access to Document

10.1055/s-2006-960863

Cite this

@article{f0a15e487b0140a29c2182d3a2c99eb1,

title = "Hemistepsins with cytotoxic activity from Hemisteptia lyrata",

abstract = "Two sesquiterpene lactones were isolated from Hemisteptia lyrata Bunge (Compositae). Their structures were elucidated by spectroscopic methods as recently known hemistepsin and the new 6-O-(2-methylpropenoyl)-3-hydroxy- 4(15), 10(14),11(13)-guaiatrien-12,8-olide. The two hemistepsin derivatives were examined for their in vitro cytotoxic activity against human cell lines such as UACC 62, HCT 15, UO-31, PC-3 and A549. Growth inhibitory property was determined by in vitro treatment of the respective cell lines using the sulforhodamine B assay (SRB). Both compounds exhibited significant cytotoxic activity (IC50 < 4.3 μg/ml) on all five human cell lines tested.",

author = "Jang, \{Dae Sik\} and Yang, \{Min Suk\} and Ha, \{Tae Joung\} and Park, \{Ki Hun\}",

year = "1999",

month = dec,

doi = "10.1055/s-2006-960863",

language = "English",

volume = "65",

pages = "765--766",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "8",

}

TY - JOUR

T1 - Hemistepsins with cytotoxic activity from Hemisteptia lyrata

AU - Jang, Dae Sik

AU - Yang, Min Suk

AU - Ha, Tae Joung

AU - Park, Ki Hun

PY - 1999/12

Y1 - 1999/12

N2 - Two sesquiterpene lactones were isolated from Hemisteptia lyrata Bunge (Compositae). Their structures were elucidated by spectroscopic methods as recently known hemistepsin and the new 6-O-(2-methylpropenoyl)-3-hydroxy- 4(15), 10(14),11(13)-guaiatrien-12,8-olide. The two hemistepsin derivatives were examined for their in vitro cytotoxic activity against human cell lines such as UACC 62, HCT 15, UO-31, PC-3 and A549. Growth inhibitory property was determined by in vitro treatment of the respective cell lines using the sulforhodamine B assay (SRB). Both compounds exhibited significant cytotoxic activity (IC50 < 4.3 μg/ml) on all five human cell lines tested.

AB - Two sesquiterpene lactones were isolated from Hemisteptia lyrata Bunge (Compositae). Their structures were elucidated by spectroscopic methods as recently known hemistepsin and the new 6-O-(2-methylpropenoyl)-3-hydroxy- 4(15), 10(14),11(13)-guaiatrien-12,8-olide. The two hemistepsin derivatives were examined for their in vitro cytotoxic activity against human cell lines such as UACC 62, HCT 15, UO-31, PC-3 and A549. Growth inhibitory property was determined by in vitro treatment of the respective cell lines using the sulforhodamine B assay (SRB). Both compounds exhibited significant cytotoxic activity (IC50 < 4.3 μg/ml) on all five human cell lines tested.

UR - https://www.scopus.com/pages/publications/0000617429

U2 - 10.1055/s-2006-960863

DO - 10.1055/s-2006-960863

M3 - Article

C2 - 10630126

AN - SCOPUS:0000617429

SN - 0032-0943

VL - 65

SP - 765

EP - 766

JO - Planta Medica

JF - Planta Medica

IS - 8

ER -

Hemistepsins with cytotoxic activity from Hemisteptia lyrata

Abstract

Access to Document

Other files and links

Fingerprint

Cite this