Abstract
2,5-Disubstituted-1,3,4-oxadiazoles are prepared in excellent yields (up to 97%) under totally solvent-free conditions by the quantitative formation of N-acylhydrazone from the reaction of a hydrazide with an aldehyde using a ball-mill for 10 min at room temperature followed by oxidation with BTI at 80°C for 1h.
Original language | English |
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Pages (from-to) | 723-727 |
Number of pages | 5 |
Journal | Bulletin of the Korean Chemical Society |
Volume | 38 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1 Jul 2017 |
Bibliographical note
Publisher Copyright:© 2017 Korean Chemical Society, Seoul & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Keywords
- 1,3,4-Oxadiazole
- Ball-mill
- N-Acylhydrazone
- Solvent-free
- [Bis(trifluoroacetoxy)iodo]benzene-oxidation