Highly Efficient One-Pot Solvent-Free Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazole via BTI-mediated Oxidation of N-Acylhydrazone from Hydrazide and Aldehyde

Xinhao Yan, Goeun Lee, Kyung Tak Noh, Hyeonjin Lee, Hakwon Kim, Kyu Hyung Lee, Nam Hwi Hur, Byeongno Lee, Young Jun Park

Research output: Contribution to journalArticlepeer-review

Abstract

2,5-Disubstituted-1,3,4-oxadiazoles are prepared in excellent yields (up to 97%) under totally solvent-free conditions by the quantitative formation of N-acylhydrazone from the reaction of a hydrazide with an aldehyde using a ball-mill for 10 min at room temperature followed by oxidation with BTI at 80°C for 1h.

Original languageEnglish
Pages (from-to)723-727
Number of pages5
JournalBulletin of the Korean Chemical Society
Volume38
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Bibliographical note

Publisher Copyright:
© 2017 Korean Chemical Society, Seoul & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • 1,3,4-Oxadiazole
  • Ball-mill
  • N-Acylhydrazone
  • Solvent-free
  • [Bis(trifluoroacetoxy)iodo]benzene-oxidation

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