Hydrotropic nanocarriers for poorly soluble drugs

Tooru Ooya; Sang Cheon Lee; Kang Moo Huh; Kinam Park

doi:10.1007/978-1-4020-5041-1_4

Hydrotropic nanocarriers for poorly soluble drugs

Tooru Ooya, Sang Cheon Lee, Kang Moo Huh, Kinam Park

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

11 Citations (Scopus)

Abstract

Delivery of poorly water-soluble drugs remains as one of the most difficult challenges in the pharmaceutics and drug delivery areas. One of the recent approaches of increasing the water-solubility of poorly soluble drugs has been to utilize polymeric hydrotropic agents. Hydrotropic agents in nanocarrier forms, such as dendrimers and polymer micelles, increase the water solubility by orders of magnitude. The hydrotropic nanocarriers have advantages over other carriers for their high drug loading efficiency and long-term stability.

Original language	English
Title of host publication	Nanocarrier Technologies
Subtitle of host publication	Frontiers of Nanotherapy
Publisher	Springer Netherlands
Pages	51-73
Number of pages	23
Volume	9781402050411
ISBN (Electronic)	9781402050411
ISBN (Print)	1402050402, 9781402050404
DOIs	https://doi.org/10.1007/978-1-4020-5041-1_4
Publication status	Published - 2006

Bibliographical note

Publisher Copyright:
© 2006 Springer. All Rights Reserved.

Keywords

Dendrimer
Hydrotropy
Nanocarrier
Paclitaxel
Polymer micelle
Water-solubility

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10.1007/978-1-4020-5041-1_4

Cite this

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AU - Huh, Kang Moo

AU - Park, Kinam

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AB - Delivery of poorly water-soluble drugs remains as one of the most difficult challenges in the pharmaceutics and drug delivery areas. One of the recent approaches of increasing the water-solubility of poorly soluble drugs has been to utilize polymeric hydrotropic agents. Hydrotropic agents in nanocarrier forms, such as dendrimers and polymer micelles, increase the water solubility by orders of magnitude. The hydrotropic nanocarriers have advantages over other carriers for their high drug loading efficiency and long-term stability.

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KW - Hydrotropy

KW - Nanocarrier

KW - Paclitaxel

KW - Polymer micelle

KW - Water-solubility

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PB - Springer Netherlands

ER -

Hydrotropic nanocarriers for poorly soluble drugs

Abstract

Bibliographical note

Keywords

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